Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management

Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management The tolerability of antidepressants is poorly characterized in children and adolescents with depressive and anxiety disorders. Among adverse events that affect the tolerability of antidepressants in youth is activation, a cluster of symptoms that represent a hyperarousal event characterized by impulsivity, restlessness, and/or insomnia. This cluster of symptoms was first identified as a side effect of selective serotonin and selective serotonin norepinephrine inhibitors (SSRIs and SSNRIs) in the early 1990s; however, activation remains poorly characterized in terms of prevalence, risk factors, and pathophysiology. This article describes the pathophysiology of antidepressant-related activation, predictors of activation and its clinical management in youth with depressive and anxiety disorders who are treated with antidepressant medications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Problems in Pediatric and Adolescent Health Care Elsevier

Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management

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Publisher
Elsevier
Copyright
Copyright © 2018 Mosby, Inc.
ISSN
1538-5442
D.O.I.
10.1016/j.cppeds.2017.12.001
Publisher site
See Article on Publisher Site

Abstract

The tolerability of antidepressants is poorly characterized in children and adolescents with depressive and anxiety disorders. Among adverse events that affect the tolerability of antidepressants in youth is activation, a cluster of symptoms that represent a hyperarousal event characterized by impulsivity, restlessness, and/or insomnia. This cluster of symptoms was first identified as a side effect of selective serotonin and selective serotonin norepinephrine inhibitors (SSRIs and SSNRIs) in the early 1990s; however, activation remains poorly characterized in terms of prevalence, risk factors, and pathophysiology. This article describes the pathophysiology of antidepressant-related activation, predictors of activation and its clinical management in youth with depressive and anxiety disorders who are treated with antidepressant medications.

Journal

Current Problems in Pediatric and Adolescent Health CareElsevier

Published: Feb 1, 2018

References

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