Anticancer activity for 4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and Their abilities to interact with lymphoendothelial cell surface markers

Anticancer activity for 4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues... The structure of the anticancer agent 4,4′-dihydroxybenzophenone-2,4-dinitrophenylhydrazone ( A-007 ) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007 's moieties. Analogue anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Anticancer activity for 4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and Their abilities to interact with lymphoendothelial cell surface markers

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Ltd
ISSN
0960-894x
DOI
10.1016/S0960-894X(02)00725-4
Publisher site
See Article on Publisher Site

Abstract

The structure of the anticancer agent 4,4′-dihydroxybenzophenone-2,4-dinitrophenylhydrazone ( A-007 ) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007 's moieties. Analogue anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed.

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Dec 2, 2002

References

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