Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways

Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in... •20C inhibits inflammatory response in LPS-induced BV-2 cells.•20C treatment obviously enhances autophagy in LPS-stimulated BV-2 cells.•20C enhances autophagy via regulating MAPKs and TLR4/Akt/mTOR signaling pathways.•20C is potential to be a drug candidate for neurodegenerative diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.04.014
Publisher site
See Article on Publisher Site

Abstract

•20C inhibits inflammatory response in LPS-induced BV-2 cells.•20C treatment obviously enhances autophagy in LPS-stimulated BV-2 cells.•20C enhances autophagy via regulating MAPKs and TLR4/Akt/mTOR signaling pathways.•20C is potential to be a drug candidate for neurodegenerative diseases.

Journal

Molecular ImmunologyElsevier

Published: Jul 1, 2018

References

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