Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre

Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre Bioorganic & Medicinal Chemistry Letters 28 (2018) 1050–1055 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre Ran Wen, Haining Lv, Yong Jiang, Pengfei Tu State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China ar ti c l e i nf o ab stra ct Article history: A phytochemical study on the roots of Pongamia pinnata afforded five new isoflavone and isoflavanone Received 14 November 2017 derivatives (1–5), including two previously undescribed phenylisoflavones possessing an 1,2-oxetane Revised 30 January 2018 ring, along with 21 known compounds (6–26) among which compound 18 is the first time to be isolated Accepted 13 February 2018 from nature. The structures of the isolated compounds were determined on the basis of 1D, 2D NMR, and Available online 15 February 2018 HRESIMS. The absolute configurations of the compounds were assigned via analysis of the specific rota- tions and circular dichroism (CD) spectra, as well as by comparison of the calculated and experimental Keywords: electronic circular dichroism (ECD) data. All the isolated compounds were evaluated for their inhibitory Pongamia pinnata effects on http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0960-894x
D.O.I.
10.1016/j.bmcl.2018.02.026
Publisher site
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Abstract

Bioorganic & Medicinal Chemistry Letters 28 (2018) 1050–1055 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Anti-inflammatory isoflavones and isoflavanones from the roots of Pongamia pinnata (L.) Pierre Ran Wen, Haining Lv, Yong Jiang, Pengfei Tu State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China ar ti c l e i nf o ab stra ct Article history: A phytochemical study on the roots of Pongamia pinnata afforded five new isoflavone and isoflavanone Received 14 November 2017 derivatives (1–5), including two previously undescribed phenylisoflavones possessing an 1,2-oxetane Revised 30 January 2018 ring, along with 21 known compounds (6–26) among which compound 18 is the first time to be isolated Accepted 13 February 2018 from nature. The structures of the isolated compounds were determined on the basis of 1D, 2D NMR, and Available online 15 February 2018 HRESIMS. The absolute configurations of the compounds were assigned via analysis of the specific rota- tions and circular dichroism (CD) spectra, as well as by comparison of the calculated and experimental Keywords: electronic circular dichroism (ECD) data. All the isolated compounds were evaluated for their inhibitory Pongamia pinnata effects on

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2018

References

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