•Our data demonstrate that PMBA can selectively modulate microglia polarization.•PMBA can inhibit the transformation of microglia into M1 phenotype and promote its transformation into M2 phenotype.•PMBA can attenuate the production of inflammatory mediators and cytokines.•The modulation of microglia M1/M2 polarization of PMBA may be related to multiple mechanisms, mainly inhibiting the activation of NF-κB and MAPK.•These findings suggest that PMBA may have the potential to treat cerebral ischemic events.
Molecular Immunology – Elsevier
Published: Mar 1, 2018
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