Anti-inflammatory effects of anisalcohol on lipopolysaccharide-stimulated BV2 microglia via selective modulation of microglia polarization and down-regulation of NF-κB p65 and JNK activation

Anti-inflammatory effects of anisalcohol on lipopolysaccharide-stimulated BV2 microglia via... •Our data demonstrate that PMBA can selectively modulate microglia polarization.•PMBA can inhibit the transformation of microglia into M1 phenotype and promote its transformation into M2 phenotype.•PMBA can attenuate the production of inflammatory mediators and cytokines.•The modulation of microglia M1/M2 polarization of PMBA may be related to multiple mechanisms, mainly inhibiting the activation of NF-κB and MAPK.•These findings suggest that PMBA may have the potential to treat cerebral ischemic events. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Anti-inflammatory effects of anisalcohol on lipopolysaccharide-stimulated BV2 microglia via selective modulation of microglia polarization and down-regulation of NF-κB p65 and JNK activation

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Publisher
Pergamon
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.01.011
Publisher site
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Abstract

•Our data demonstrate that PMBA can selectively modulate microglia polarization.•PMBA can inhibit the transformation of microglia into M1 phenotype and promote its transformation into M2 phenotype.•PMBA can attenuate the production of inflammatory mediators and cytokines.•The modulation of microglia M1/M2 polarization of PMBA may be related to multiple mechanisms, mainly inhibiting the activation of NF-κB and MAPK.•These findings suggest that PMBA may have the potential to treat cerebral ischemic events.

Journal

Molecular ImmunologyElsevier

Published: Mar 1, 2018

References

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