1 Introduction</h5> Chlorogenic acid (CHA) is a common polyphenol and is contained in various foods and beverages. Coffee, one of the most widely consumed beverages in the world, is a major source of CHA in the diet, with a daily intake of approximately 1 g in coffee drinkers. Other dietary sources of CHA include fruits, such as apples, pears, and berries ( Clifford, 1999 ). It has been reported that CHA has potent antioxidative and free radical-scavenging activities in vitro ( Kono et al., 1997 ). CHA also increases the resistance of LDL to lipid peroxidation ( Laranjinha, Vierira, Almeida, & Madeira, 1996 ) and inhibits DNA damage ( Shibata, Sakamoto, Oka, & Kono, 1999 ). Furthermore, CHA inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells ( Shan et al., 2009 ). These antioxidative and anti-inflammatory effects suggest that CHA could aid in the prevention of cardiovascular diseases. Administration of dietary CHA was found to decrease the incidence of chemical carcinogenesis in the colon, liver, and tongue of animal models of cancer ( Mori, Tanaka, Shima, Kuniyasu, & Takahashi, 1986; Tanaka et al., 1990, 1993 ). CHA also shows suppressive effects on skin tumour promotion induced by chemical carcinogens
Food Chemistry – Elsevier
Published: Feb 1, 2015
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