Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress 1 1 Both authors contributed equally to this work.

Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress 1 1... This review highlights new information gained from studies using recently developed animal models that harbor specific alterations in corticotropin-releasing hormone (CRH) pathways. We discuss features of a transgenic mouse model of chronic CRH overexpression and two mouse models that lack either CRH receptor type 1 (CRH-R1) or type 2 (CRH-R2). Together these models provide new insights into the role of CRH pathways in promoting stability through adaptive changes, a process known as allostasis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress 1 1 Both authors contributed equally to this work.

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
0196-9781
DOI
10.1016/S0196-9781(01)00386-2
Publisher site
See Article on Publisher Site

Abstract

This review highlights new information gained from studies using recently developed animal models that harbor specific alterations in corticotropin-releasing hormone (CRH) pathways. We discuss features of a transgenic mouse model of chronic CRH overexpression and two mouse models that lack either CRH receptor type 1 (CRH-R1) or type 2 (CRH-R2). Together these models provide new insights into the role of CRH pathways in promoting stability through adaptive changes, a process known as allostasis.

Journal

PeptidesElsevier

Published: May 1, 2001

References

  • Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats
    Arase, K.
  • Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1
    Contarino, A.
  • Stress, adaptation and disease
    McEwen, B.S.
  • Cardiac inotropic actions of urocortin in conscious sheep
    Parkes, D.G.
  • Ethology and neurobiology of grooming behavior
    Spruijt, B.M.; van Hooff, J.A.; Gispen, W.H.

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