Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats

Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake... Intake of either hypotonic or hypertonic saline solutions is modulated in part by the endogenous opioid system. Morphine and selective mu and delta opioid agonists increase saline intake, while general opioid antagonists reduce saline intake in rats. The present study evaluated whether intracerebroventricular administration of general (naltrexone) and selective mu (beta-funaltrexamins, 5–20 μg), mu 1 (naloxonazine, 50 μg), kappa (nor-binaltorphamine, 5–20 μg), delta (naltrindole, 20 μg), or delta, (DALCE, 40 μg) opioid receptor subtype antagonists altered water intake and either hypotonic (0.6%) or hypertonic (1.7%) saline intake in water-deprived (24 h) rats over a 3-h time course in a two-bottle choice test. Whereas peripheral naltrexone (0.5–2.5 mg/kg) significantly reduced water intake and hypertonic saline intake, central naltrexone (1–50 μg) significantly reduced water intake and hypotonic saline intake. Water intake was significantly reduced following mu and kappa receptor antagonism, but not following mu 1 , delta, or delta 1 receptor antagonism. In contrast, neither hypotonic nor hypertonic saline intake was significantly altered by any selective antagonist. These data are discussed in terms of opioid receptor subtype control over saline intake relative to the animal's hydrational state and the roles of palatability and/or salt appetite. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Bulletin Elsevier

Analysis of central opioid receptor subtype antagonism of hypotonic and hypertonic saline intake in water-deprived rats

Loading next page...
 
/lp/elsevier/analysis-of-central-opioid-receptor-subtype-antagonism-of-hypotonic-74PqV0L7VH
Publisher
Elsevier
Copyright
Copyright © 1994 Elsevier Ltd
ISSN
0361-9230
eISSN
1873-2747
DOI
10.1016/0361-9230(94)00205-F
Publisher site
See Article on Publisher Site

Abstract

Intake of either hypotonic or hypertonic saline solutions is modulated in part by the endogenous opioid system. Morphine and selective mu and delta opioid agonists increase saline intake, while general opioid antagonists reduce saline intake in rats. The present study evaluated whether intracerebroventricular administration of general (naltrexone) and selective mu (beta-funaltrexamins, 5–20 μg), mu 1 (naloxonazine, 50 μg), kappa (nor-binaltorphamine, 5–20 μg), delta (naltrindole, 20 μg), or delta, (DALCE, 40 μg) opioid receptor subtype antagonists altered water intake and either hypotonic (0.6%) or hypertonic (1.7%) saline intake in water-deprived (24 h) rats over a 3-h time course in a two-bottle choice test. Whereas peripheral naltrexone (0.5–2.5 mg/kg) significantly reduced water intake and hypertonic saline intake, central naltrexone (1–50 μg) significantly reduced water intake and hypotonic saline intake. Water intake was significantly reduced following mu and kappa receptor antagonism, but not following mu 1 , delta, or delta 1 receptor antagonism. In contrast, neither hypotonic nor hypertonic saline intake was significantly altered by any selective antagonist. These data are discussed in terms of opioid receptor subtype control over saline intake relative to the animal's hydrational state and the roles of palatability and/or salt appetite.

Journal

Brain Research BulletinElsevier

Published: Jan 1, 1995

References

  • Naloxone suppresses fluid consumption in tests of choice between sodium chloride solutions and water in male and female water-deprived rats
    Cooper, S.J.; Gilbert, D.B.
  • Effects of a selective mu opioid receptor agonist and naloxone on the intake of sodium chloride solutions
    Gosnell, B.A.; Majchrzak, M.J.
  • Absence of sodium chloride preference in Fischer 344 rats
    Midkiff, E.E.; Fitts, D.A.; Simpson, J.B.; Bernstein, I.L.
  • Interaction of osmotic and volume stimuli in regulation of neurohypophyseal secretion in rats
    Stricker, E.M.; Verbalis, J.G.
  • Suppression of deprivation-induced water intake by opioid antagonists: Central sites of action
    Ukai, M.; Holtzman, S.G.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off