An association between periodontal disease and peripheral vascular disease

An association between periodontal disease and peripheral vascular disease Background: Periodontal disease has been shown to be associated with increased risk of coronary heart disease. Because coronary heart disease and peripheral vascular disease (PVD) have similar pathophysiologies, we hypothesized that periodontal disease might be a risk factor for PVD. Methods: Using the combined data from the Normative Aging Study and Dental Longitudinal Study of the US Department of Veterans Affairs, we examined the relationship between PVD and periodontal disease. Multivariate logistic regression analysis was used. Results: Over the 25 to 30 years of follow-up, 80 of these initially healthy subjects developed PVD. Compared with controls (n = 1,030), subjects with clinically significant periodontal disease at baseline had a 2.27 increment in the risk of developing PVD (95% confidence interval 1.32 to 3.9, P value = 0.003). Conclusions: Periodontal disease emerged as a significant independent risk factor for PVD in a multivariate analysis that adjusted for other established risk factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal of Surgery Elsevier

An association between periodontal disease and peripheral vascular disease

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Publisher
Elsevier
Copyright
Copyright © 1998 Excerpta Medica Inc.
ISSN
0002-9610
DOI
10.1016/S0002-9610(98)00158-5
Publisher site
See Article on Publisher Site

Abstract

Background: Periodontal disease has been shown to be associated with increased risk of coronary heart disease. Because coronary heart disease and peripheral vascular disease (PVD) have similar pathophysiologies, we hypothesized that periodontal disease might be a risk factor for PVD. Methods: Using the combined data from the Normative Aging Study and Dental Longitudinal Study of the US Department of Veterans Affairs, we examined the relationship between PVD and periodontal disease. Multivariate logistic regression analysis was used. Results: Over the 25 to 30 years of follow-up, 80 of these initially healthy subjects developed PVD. Compared with controls (n = 1,030), subjects with clinically significant periodontal disease at baseline had a 2.27 increment in the risk of developing PVD (95% confidence interval 1.32 to 3.9, P value = 0.003). Conclusions: Periodontal disease emerged as a significant independent risk factor for PVD in a multivariate analysis that adjusted for other established risk factors.

Journal

The American Journal of SurgeryElsevier

Published: Aug 1, 1998

References

  • Design and analysis considerations for a longitudinal study of periodontal disease
    Feldman, R.S; Alman, J.E; Chauncey, H.H
  • Cytomegalovirus DNA in arterial walls of patients with atherosclerosis
    Melnick, J.L; Hu, C.H; Burek, J

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