Available online at www.sciencedirect.com ScienceDirect Ambient surface mass spectrometry–ion mobility spectrometry of intact proteins Rian L Grifﬁths, Klaudia I Kocurek and Helen J Cooper Ambient surface mass spectrometry encompasses a broad The ability to probe solid substrates directly offers range of sampling and ionization techniques. To date, only a several advantages over analysis of liquid samples; most small subset of these, based on liquid microjunction extraction, obviously, the opportunity to access spatial information have proven suitable for intact protein analysis from thin tissue (e.g., to perform mass spectrometry imaging). For clini- sections. Liquid extraction surface analysis shows particular cal samples, solid substrates may present a safer option promise for this application. Recently, a range of ion mobility than liquid samples: In the case of dried blood spots, spectrometry approaches have been coupled with ambient for example, infections such as HIV cannot survive mass spectrometry. Improvements in signal-to-noise ratios, the drying process , thus they are safer than whole decreased chemical noise and separation of molecular classes blood. have been described for the analysis of various biological substrates. Similar beneﬁts have been described for ambient This review focuses on the application of ambient ioniza- mass spectrometry imaging studies. In this
Current Opinion in Chemical Biology – Elsevier
Published: Feb 1, 2018
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