Ambient surface mass spectrometry–ion mobility spectrometry of intact proteins

Ambient surface mass spectrometry–ion mobility spectrometry of intact proteins Available online at www.sciencedirect.com ScienceDirect Ambient surface mass spectrometry–ion mobility spectrometry of intact proteins Rian L Griffiths, Klaudia I Kocurek and Helen J Cooper Ambient surface mass spectrometry encompasses a broad The ability to probe solid substrates directly offers range of sampling and ionization techniques. To date, only a several advantages over analysis of liquid samples; most small subset of these, based on liquid microjunction extraction, obviously, the opportunity to access spatial information have proven suitable for intact protein analysis from thin tissue (e.g., to perform mass spectrometry imaging). For clini- sections. Liquid extraction surface analysis shows particular cal samples, solid substrates may present a safer option promise for this application. Recently, a range of ion mobility than liquid samples: In the case of dried blood spots, spectrometry approaches have been coupled with ambient for example, infections such as HIV cannot survive mass spectrometry. Improvements in signal-to-noise ratios, the drying process [2], thus they are safer than whole decreased chemical noise and separation of molecular classes blood. have been described for the analysis of various biological substrates. Similar benefits have been described for ambient This review focuses on the application of ambient ioniza- mass spectrometry imaging studies. In this http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Chemical Biology Elsevier

Ambient surface mass spectrometry–ion mobility spectrometry of intact proteins

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Publisher
Elsevier
Copyright
Copyright © 2017 The Authors
ISSN
1367-5931
D.O.I.
10.1016/j.cbpa.2017.11.002
Publisher site
See Article on Publisher Site

Abstract

Available online at www.sciencedirect.com ScienceDirect Ambient surface mass spectrometry–ion mobility spectrometry of intact proteins Rian L Griffiths, Klaudia I Kocurek and Helen J Cooper Ambient surface mass spectrometry encompasses a broad The ability to probe solid substrates directly offers range of sampling and ionization techniques. To date, only a several advantages over analysis of liquid samples; most small subset of these, based on liquid microjunction extraction, obviously, the opportunity to access spatial information have proven suitable for intact protein analysis from thin tissue (e.g., to perform mass spectrometry imaging). For clini- sections. Liquid extraction surface analysis shows particular cal samples, solid substrates may present a safer option promise for this application. Recently, a range of ion mobility than liquid samples: In the case of dried blood spots, spectrometry approaches have been coupled with ambient for example, infections such as HIV cannot survive mass spectrometry. Improvements in signal-to-noise ratios, the drying process [2], thus they are safer than whole decreased chemical noise and separation of molecular classes blood. have been described for the analysis of various biological substrates. Similar benefits have been described for ambient This review focuses on the application of ambient ioniza- mass spectrometry imaging studies. In this

Journal

Current Opinion in Chemical BiologyElsevier

Published: Feb 1, 2018

References

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