Aluminum exposure for 60days at an equivalent human dietary level promotes peripheral dysfunction in rats

Aluminum exposure for 60days at an equivalent human dietary level promotes peripheral dysfunction... Aluminum (Al) is a neurotoxic associated with a number of chronic human diseases. We investigated the effects of Al exposure at doses similar to human dietary levels and at a high level exposure to Al on the peripheral nervous system. Wistar male rats were divided into two major groups and received orally: 1) First group – Low level - rats were subdivided and treated for 60days: a) Control – received ultrapure water; b) AlCl3 – received Al at 8.3mg/kg body weight (bw) for 60days; and 2) Second group – High level - rats were subdivided and treated for 42days: C) Control – received ultrapure water through oral gavage; d) AlCl3 – received Al at 100mg/kg bw for 42days. Von Frey hair test, plantar test, the presence of catalepsy and the spontaneous motor activity were investigated. Reactive oxygen species, lipid peroxidation and total antioxidant capacity, immunohistochemistry to investigate the nerve inflammation and, the specific presence of Al in the sciatic nerve fibers were investigated. Al exposure at a representative human dietary level promotes the development of mechanical allodynia, catalepsy, increased inflammation in the sciatic nerve, systemic oxidative stress and, is able to be retained in the sciatic nerve. The effects of low-dose Al were similar to those found in rats exposed to Al at a dose much higher (100mg/kg). Our findings suggest that Al may be considered toxic for the peripheral nervous system, thus inducing peripheral dysfunction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Inorganic Biochemistry Elsevier

Aluminum exposure for 60days at an equivalent human dietary level promotes peripheral dysfunction in rats

Loading next page...
 
/lp/elsevier/aluminum-exposure-for-60days-at-an-equivalent-human-dietary-level-zHLjqFit0R
Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
0162-0134
eISSN
1873-3344
D.O.I.
10.1016/j.jinorgbio.2017.08.011
Publisher site
See Article on Publisher Site

Abstract

Aluminum (Al) is a neurotoxic associated with a number of chronic human diseases. We investigated the effects of Al exposure at doses similar to human dietary levels and at a high level exposure to Al on the peripheral nervous system. Wistar male rats were divided into two major groups and received orally: 1) First group – Low level - rats were subdivided and treated for 60days: a) Control – received ultrapure water; b) AlCl3 – received Al at 8.3mg/kg body weight (bw) for 60days; and 2) Second group – High level - rats were subdivided and treated for 42days: C) Control – received ultrapure water through oral gavage; d) AlCl3 – received Al at 100mg/kg bw for 42days. Von Frey hair test, plantar test, the presence of catalepsy and the spontaneous motor activity were investigated. Reactive oxygen species, lipid peroxidation and total antioxidant capacity, immunohistochemistry to investigate the nerve inflammation and, the specific presence of Al in the sciatic nerve fibers were investigated. Al exposure at a representative human dietary level promotes the development of mechanical allodynia, catalepsy, increased inflammation in the sciatic nerve, systemic oxidative stress and, is able to be retained in the sciatic nerve. The effects of low-dose Al were similar to those found in rats exposed to Al at a dose much higher (100mg/kg). Our findings suggest that Al may be considered toxic for the peripheral nervous system, thus inducing peripheral dysfunction.

Journal

Journal of Inorganic BiochemistryElsevier

Published: Apr 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off