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The Agouti - Related Protein (AgRP) is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally. AgRP-deficiency, on the other hand, leads ...
The agouti signaling protein (ASIP) and its homolog, the agouti ‐ related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals. NMR ...
- related protein (AgRP) are potent food-stimulating neuropeptides that are highly co-localised in arcuate nucleus neurons of the hypothalamus. Recent studies have shown that NPY and AgRP mRNA levels ...
., 57, 890–898 (2000). 15) Haskell-Luevano, C., and Monck, E. K., Agouti - related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regul. Pept., 99, 1–7 ...
affinities for the agonist and endogenous antagonist agouti ‐ related protein . Signalling assays showed that S136F is defective in signalling. Multiple mutagenesis showed that S136 of hMC4R is required ...
- related protein (AgRP), the endogenous inverse agonist at the MC-4 receptor, was found to affect two hallmark features of cachexia, i.e. to increase food intake and to reduce energy expenditure. Methodology ...
in the hypothalamus. food intake; G protein -coupled receptor; body weight; agouti - related protein ; immunization Address for reprint requests and other correspondence: K. G. Hofbauer, Applied Pharmacology, Biozentrum ...
. Agouti - related peptide (AgRP) is a small protein factor that is part of the melanocortin system and acts as an inverse agonist on the MC3 and MC4 receptors. AgRP co-exists with neuropeptide Y (NPY ...
The interaction of melanocortin-4 (MC4R) and melanocortin-3 (MC3R) receptors with proopiomelanocortin (POMC)-derived peptides (e.g. α-MSH), agouti - related protein (AgRP) and melanocortin-2 receptor ...
The interaction of melanocortin-4 (MC4R) and melanocortin-3 (MC3R) receptors with proopiomelanocortin (POMC)-derived peptides(e.g. α-MSH), agouti - related protein (AgRP) and melanocortin-2 receptor ...
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