AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease

AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a... IntroductionAF710B (aka ANAVEX 3-71) is a novel selective allosteric M1 muscarinic and sigma-1 receptor agonist. In 3×Tg-AD mice, AF710B attenuates cognitive deficits and decreases Alzheimer-like hallmarks. We now report on the long-lasting disease-modifying properties of AF710B in McGill-R-Thy1-APP transgenic (Tg) rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alzheimer's and Dementia Elsevier

AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease

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Publisher
Elsevier
Copyright
Copyright © 2017 the Alzheimer's Association
ISSN
1552-5260
D.O.I.
10.1016/j.jalz.2017.11.009
Publisher site
See Article on Publisher Site

Abstract

IntroductionAF710B (aka ANAVEX 3-71) is a novel selective allosteric M1 muscarinic and sigma-1 receptor agonist. In 3×Tg-AD mice, AF710B attenuates cognitive deficits and decreases Alzheimer-like hallmarks. We now report on the long-lasting disease-modifying properties of AF710B in McGill-R-Thy1-APP transgenic (Tg) rats.

Journal

Alzheimer's and DementiaElsevier

Published: Jun 1, 2018

References

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