Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine

Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine 1. 1. There is a large body of evidence indicating that fenfluramines damage brain serotonin neurons in animals. 2. 2. Little is known about potential adverse neuropsychiatric consequences in humans associated with use of fenfluramines that could potentially be related to serotonergic dysfunction. 3. 3. The authors now report numerous cases of severe and, sometimes persistent, neuropsychiatric syndromes associated with fenfluramine use. 4. 4. Thirty one representative cases are presented and summarized in table form. 5. 5. Several of the cases presented suggest long-lasting deleterious effects of fenfluramines on brain serotonin function. 6. 6. Clinicians should be vigilant for disorders of mood, anxiety, cognitive function and impulse control in patients previously exposed to fenfluramines . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Neuro-Psychopharmacology & Biological Psychiatry Elsevier

Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Ltd
ISSN
0278-5846
eISSN
1878-4216
DOI
10.1016/S0278-5846(98)00063-3
Publisher site
See Article on Publisher Site

Abstract

1. 1. There is a large body of evidence indicating that fenfluramines damage brain serotonin neurons in animals. 2. 2. Little is known about potential adverse neuropsychiatric consequences in humans associated with use of fenfluramines that could potentially be related to serotonergic dysfunction. 3. 3. The authors now report numerous cases of severe and, sometimes persistent, neuropsychiatric syndromes associated with fenfluramine use. 4. 4. Thirty one representative cases are presented and summarized in table form. 5. 5. Several of the cases presented suggest long-lasting deleterious effects of fenfluramines on brain serotonin function. 6. 6. Clinicians should be vigilant for disorders of mood, anxiety, cognitive function and impulse control in patients previously exposed to fenfluramines .

Journal

Progress in Neuro-Psychopharmacology & Biological PsychiatryElsevier

Published: Oct 1, 1998

References

  • Extrapolation of toxicological and pharmacological data from animals to humans
    Chappell, W.; Mordenti, J.
  • Fenfluramine: neurotoxicity
    Schuster, CR; Lewis, M; Seiden, LS

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