Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5⿲ triphosphate (ATP)

Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5⿲ triphosphate (ATP) Article history: ATP is a well-known energy supplier in cells. The idea to associate ATP to pharmaceutical Received 27 August 2015 formulations/biotechnological devices to promote cells activity by potentially modulating their microen- Received in revised form 9 November 2015 vironment thus appears as an appealing novel approach. Since biomimetic nanocrystalline apatites have Accepted 9 November 2015 shown great promise for biomedical applications (bone regeneration, cells diagnostics/therapeutics, . . .), Available online 14 November 2015 thanks to a high surface reactivity and an intrinsically high biocompatibility, the present contribution was aimed at exploring ATP/apatite interactions. ATP adsorption on a synthetic carbonated nanocrystalline Keywords: apatite preliminarily characterized (by XRD, FTIR, Raman, TG-DTA and SEM-EDX) was investigated in Nanocrystalline apatite detail, pointing out a good agreement with Sips isothermal features. Adsorption characteristics were Adenosine triphosphate compared to those previously obtained on monophosphate nucleotides (AMP, CMP), unveiling some Adsorption specificities. ATP was found to adsorb effectively onto biomimetic apatite: despite smaller values of the Nucleotide Vibrational spectroscopy affinity constant K and the exponential factor m, larger adsorbed amounts were reached for ATP as compared to AMP for any given concentration in solution. m < 1 suggests that the ATP/apatite adsorp- tion process is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Surface Science Elsevier

Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5⿲ triphosphate (ATP)

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Publisher
Elsevier
Copyright
Copyright © 2015 Elsevier B.V.
ISSN
0169-4332
eISSN
1873-5584
D.O.I.
10.1016/j.apsusc.2015.11.100
Publisher site
See Article on Publisher Site

Abstract

Article history: ATP is a well-known energy supplier in cells. The idea to associate ATP to pharmaceutical Received 27 August 2015 formulations/biotechnological devices to promote cells activity by potentially modulating their microen- Received in revised form 9 November 2015 vironment thus appears as an appealing novel approach. Since biomimetic nanocrystalline apatites have Accepted 9 November 2015 shown great promise for biomedical applications (bone regeneration, cells diagnostics/therapeutics, . . .), Available online 14 November 2015 thanks to a high surface reactivity and an intrinsically high biocompatibility, the present contribution was aimed at exploring ATP/apatite interactions. ATP adsorption on a synthetic carbonated nanocrystalline Keywords: apatite preliminarily characterized (by XRD, FTIR, Raman, TG-DTA and SEM-EDX) was investigated in Nanocrystalline apatite detail, pointing out a good agreement with Sips isothermal features. Adsorption characteristics were Adenosine triphosphate compared to those previously obtained on monophosphate nucleotides (AMP, CMP), unveiling some Adsorption specificities. ATP was found to adsorb effectively onto biomimetic apatite: despite smaller values of the Nucleotide Vibrational spectroscopy affinity constant K and the exponential factor m, larger adsorbed amounts were reached for ATP as compared to AMP for any given concentration in solution. m < 1 suggests that the ATP/apatite adsorp- tion process is

Journal

Applied Surface ScienceElsevier

Published: Jan 1, 2016

References

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