Adiponectin and leptin are related to fat mass in horses

Adiponectin and leptin are related to fat mass in horses Plasma concentrations of adiponectin and leptin were measured in 23 mature Standardbred mares (age: 10 ± 3 years) and 12 weanling fillies (10 Quarter Horse/Belgian crossbreds and two Quarter Horses; aged: 4 ± 3 months) to test the hypothesis that adipocytokines are proportional to adiposity in horses. Rump fat thickness was measured using B-mode ultrasound and percent body fat (% fat) calculated using a published formula for the estimation of fatness in horses. Plasma adiponectin and leptin were determined using radioimmunoassay. In the absence of purified equine adiponectin or leptin, results were expressed as human equivalents (HE) of immunoreactive (ir) adipocytokines. Plasma ir-leptin HE concentration was positively correlated ( r = 0.543; P < 0.001) with percent body fat and ( r = 0.556; P < 0.001) to fat mass in all horses. The plasma ir-leptin HE concentration was lower ( P = 0.03) in weanlings (1.90 ± 0.34 ng/mL HE) than in mature mares (3.47 ± 0.50 ng/mL HE). The ratio of ir-adiponectin HE to ir-leptin HE was negatively correlated ( r = −0.621; P < 0.001) to percent fat and ( r = −631; P < 0.001) to fat mass in all horses. The ratio of ir-adiponectin HE to ir-leptin HE was higher ( P < 0.001) in weanlings (3.04 ± 0.51) than mature mares (1.03 ± 0.13). These data suggest that leptin is proportional while adiponectin is inversely proportional to adiposity in horses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Veterinary Journal Elsevier

Adiponectin and leptin are related to fat mass in horses

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Abstract

Plasma concentrations of adiponectin and leptin were measured in 23 mature Standardbred mares (age: 10 ± 3 years) and 12 weanling fillies (10 Quarter Horse/Belgian crossbreds and two Quarter Horses; aged: 4 ± 3 months) to test the hypothesis that adipocytokines are proportional to adiposity in horses. Rump fat thickness was measured using B-mode ultrasound and percent body fat (% fat) calculated using a published formula for the estimation of fatness in horses. Plasma adiponectin and leptin were determined using radioimmunoassay. In the absence of purified equine adiponectin or leptin, results were expressed as human equivalents (HE) of immunoreactive (ir) adipocytokines. Plasma ir-leptin HE concentration was positively correlated ( r = 0.543; P < 0.001) with percent body fat and ( r = 0.556; P < 0.001) to fat mass in all horses. The plasma ir-leptin HE concentration was lower ( P = 0.03) in weanlings (1.90 ± 0.34 ng/mL HE) than in mature mares (3.47 ± 0.50 ng/mL HE). The ratio of ir-adiponectin HE to ir-leptin HE was negatively correlated ( r = −0.621; P < 0.001) to percent fat and ( r = −631; P < 0.001) to fat mass in all horses. The ratio of ir-adiponectin HE to ir-leptin HE was higher ( P < 0.001) in weanlings (3.04 ± 0.51) than mature mares (1.03 ± 0.13). These data suggest that leptin is proportional while adiponectin is inversely proportional to adiposity in horses.

Journal

The Veterinary JournalElsevier

Published: Nov 1, 2006

References

  • Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes
    Fasshauer, M.; Klein, J.; Neumann, S.; Eszlinger, M.; Paschke, R.
  • Overview of horse body composition and muscle architecture: implications for performance
    Kearns, C.F.; McKeever, K.H.; Abe, T.
  • Relationship between body composition, blood volume and maximal oxygen uptake
    Kearns, C.F.; McKeever, K.H.; John-Alder, H.; Brechue, W.F.; Abe, T.
  • Fat-free mass is related to one mile race performance in elite Standardbred horses
    Kearns, C.F.; McKeever, K.H.; Kumagai, K.; Abe, T.
  • Effect of training on age-related changes in plasma insulin and glucose
    Malinowski, K.; Betros, C.L.; Flora, L.; Kearns, C.F.; McKeever, K.H.
  • Decreased glucose metabolism causes separation of hoof lamellae in vitro: a trigger for laminitis
    Pass, M.A.; Pollitt, S.; Pollitt, C.C.

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