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4 (L4) through activation of pre- and/or postsynaptically located adenosine A1 receptors . In recurrent excitatory connections between L4 spiny neurons, adenosine suppresses synaptic transmission ...
presynaptic (inhibitory, which are A1‐ receptor mediated; and excitatory , which are A2A‐ receptor mediated) effects, the action of adenosine on transmitter release depends on the intensity of stimulation ...
adenosine receptor type 1 A 2A R adenosine receptor type 2A Ado adenosine APV d ‐(−)‐2‐amino‐5‐phosphonopentanoic acid DPCPX 8‐cyclopentyl‐1,3‐dipropylxanthine (A 1 R antagonist) mEPSP miniature excitatory ...
(eIPSCs), suggesting a presynaptic modulation of the probability of GABA release. In addition, CXCL16 increases the frequency of the miniature excitatory synaptic currents (mEPSCs) and reduces the PPR ...
‐ synaptic currents (sEPSCs, ~35% reduction) without affecting the amplitude in dentate gyrus (DG) granule cells. Pretreatment with the adenosine A1 receptor (A1R) antagonist, DPCPX, abolished the J7 effects ...
the evidence suggesting that in some striatal excitatory synapses, adenosine can provide the heterosynaptic-like modulation essential for stabilizing homosynaptic plasticity without the need of a "third ...
1 . We have used the whole‐cell patch‐clamp recording technique to examine the modulation of dual‐component excitatory postsynaptic currents (EPSCs) in CA1 pyramidal cells in guinea‐pig hippocampal ...
, such as activation of presynaptic gamma-aminobutyric acid-B receptors by baclofen, blockade of presynaptic adenosine receptors by theophylline, blockade of presynaptic potassium channels by cesium, and increasing ...
/scientificreports OPEN Input‑selective adenosine A receptor ‑mediated synaptic depression of excitatory transmission in dorsal striatum 1 1 1,2* Brandon M. Fritz , Fuqin Yin & Brady K. Atwood The medial (DMS ...
1 Histaminergic depression of excitatory synaptic transmission in the rat dentate gyrus was investigated using extracellular and whole‐cell patch‐clamp recording techniques in vitro. 2 Application ...
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