Acute rise in corticosterone facilitates 5-HT 1A receptor-mediated behavioural responses

Acute rise in corticosterone facilitates 5-HT 1A receptor-mediated behavioural responses Corticosterone influences 5-HT 1A receptor-mediated responses in the rat hippocampus in vitro: activation of the high affinity mineralocorticoid receptor suppresses 5-HT 1A receptor-mediated hyperpolarization, while subsequent activation of lower affinity glucocorticoid receptors enhances the effect of 5-HT. We have tested whether a similar effect of corticosterone exists in vivo. In intact rats, a systemic injection of the specific 5-HT 1A receptor agonist, 8-OH-DPAT (8-hydroxy-2-(di- n -propylamino)tetralin), led to increased locomotion and to a less persistent search strategy in the free swim trial of the Morris water maze test. Adrenalectomized rats with a corticosterone-pellet implanted as replacement received an injection of vehicle (predominant mineralocorticoid receptor occupation) or a high dose of corticosterone (both corticosteroid receptor types occupied) 1 h before injection of 8-OH-DPAT. The effect on search strategy, but not on locomotor activity, was less in animals with low corticosterone levels. The results suggest that hippocampal 5-HT 1A receptor-mediated responses in vivo are attenuated during predominant activation of the mineralocorticoid receptor and increased after additional transient activation of the glucocorticoid receptor. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Acute rise in corticosterone facilitates 5-HT 1A receptor-mediated behavioural responses

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(98)00289-1
Publisher site
See Article on Publisher Site

Abstract

Corticosterone influences 5-HT 1A receptor-mediated responses in the rat hippocampus in vitro: activation of the high affinity mineralocorticoid receptor suppresses 5-HT 1A receptor-mediated hyperpolarization, while subsequent activation of lower affinity glucocorticoid receptors enhances the effect of 5-HT. We have tested whether a similar effect of corticosterone exists in vivo. In intact rats, a systemic injection of the specific 5-HT 1A receptor agonist, 8-OH-DPAT (8-hydroxy-2-(di- n -propylamino)tetralin), led to increased locomotion and to a less persistent search strategy in the free swim trial of the Morris water maze test. Adrenalectomized rats with a corticosterone-pellet implanted as replacement received an injection of vehicle (predominant mineralocorticoid receptor occupation) or a high dose of corticosterone (both corticosteroid receptor types occupied) 1 h before injection of 8-OH-DPAT. The effect on search strategy, but not on locomotor activity, was less in animals with low corticosterone levels. The results suggest that hippocampal 5-HT 1A receptor-mediated responses in vivo are attenuated during predominant activation of the mineralocorticoid receptor and increased after additional transient activation of the glucocorticoid receptor.

Journal

European Journal of PharmacologyElsevier

Published: Jun 12, 1998

References

  • Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro
    Andrade, R; Nicoll, R.A
  • 8-Hydroxy-2-(di- n -propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5-HT 1a receptors
    Carli, M; Samanin, R
  • 8-OH-DPAT impairs spatial but not visual learning in a water maze by stimulating 5-HT 1A receptors in the hippocampus
    Carli, M; Luschi, R; Garofalo, P; Samanin, R
  • The involvement of serotonin in regulation of pituitary–adrenocortical function
    Fuller, R.W
  • A role for the mineralocorticoid receptor in a rapid and transient suppression of 5-HT 1A receptor mRNA by corticosterone
    Meijer, O.C; De Kloet, E.R
  • Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus
    Van Eekelen, J.A.M; Jiang, W; De Kloet, E.R; Bohn, M.C

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