Prostate cancer (PCa) is a highly heterogeneous disease, often with a long natural history. Nearly 240,000 men in the United States are diagnosed with PCa annually, and >90% of these patients have local disease. 1 The incidence/mortality ratio for PCa is approximately 8, which is higher than any other major cancer, and patients with a low-risk disease have a greater probability of dying from causes other than PCa, even 20 years after diagnosis. 2 Thought leaders have questioned if low-grade PCa has the capability to metastasize, 3 and some have proposed that certain low-grade lesions no longer be referred to as “cancer.” 4 </P>Watchful waiting (WW) refers to conservative management of PCa until the development of local or systemic progression, the point at which palliative measures are used. A recognized alternative to WW or active intervention is the active surveillance (AS): a therapeutic strategy that involves monitoring the patient's disease through repeated biomarker testing, physical examination, imaging, and prostate biopsies to provide additional information about the disease over time. The goal of AS is twofold for those: (1) who experience progression, to identify progression early enough that there is a potential to intervene without significant diminution of oncologic
Urology – Elsevier
Published: Dec 1, 2014
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera