Active Surveillance of Prostate Cancer in African American Men

Active Surveillance of Prostate Cancer in African American Men Prostate cancer (PCa) is a highly heterogeneous disease, often with a long natural history. Nearly 240,000 men in the United States are diagnosed with PCa annually, and >90% of these patients have local disease. 1 The incidence/mortality ratio for PCa is approximately 8, which is higher than any other major cancer, and patients with a low-risk disease have a greater probability of dying from causes other than PCa, even 20 years after diagnosis. 2 Thought leaders have questioned if low-grade PCa has the capability to metastasize, 3 and some have proposed that certain low-grade lesions no longer be referred to as “cancer.” 4 </P>Watchful waiting (WW) refers to conservative management of PCa until the development of local or systemic progression, the point at which palliative measures are used. A recognized alternative to WW or active intervention is the active surveillance (AS): a therapeutic strategy that involves monitoring the patient's disease through repeated biomarker testing, physical examination, imaging, and prostate biopsies to provide additional information about the disease over time. The goal of AS is twofold for those: (1) who experience progression, to identify progression early enough that there is a potential to intervene without significant diminution of oncologic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Urology Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2014 Elsevier Ltd
ISSN
0090-4295
DOI
10.1016/j.urology.2014.06.064
pmid
25283702
Publisher site
See Article on Publisher Site

Abstract

Prostate cancer (PCa) is a highly heterogeneous disease, often with a long natural history. Nearly 240,000 men in the United States are diagnosed with PCa annually, and >90% of these patients have local disease. 1 The incidence/mortality ratio for PCa is approximately 8, which is higher than any other major cancer, and patients with a low-risk disease have a greater probability of dying from causes other than PCa, even 20 years after diagnosis. 2 Thought leaders have questioned if low-grade PCa has the capability to metastasize, 3 and some have proposed that certain low-grade lesions no longer be referred to as “cancer.” 4 </P>Watchful waiting (WW) refers to conservative management of PCa until the development of local or systemic progression, the point at which palliative measures are used. A recognized alternative to WW or active intervention is the active surveillance (AS): a therapeutic strategy that involves monitoring the patient's disease through repeated biomarker testing, physical examination, imaging, and prostate biopsies to provide additional information about the disease over time. The goal of AS is twofold for those: (1) who experience progression, to identify progression early enough that there is a potential to intervene without significant diminution of oncologic

Journal

UrologyElsevier

Published: Dec 1, 2014

References

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