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pathway from VLPO to the locus coeruleus (LC), we compared the inhibition effect of propofol on the LC activity before and after VLPO lesion in vivo rats . Systemic administration of propofol (20 mg/kg, i.p ...
of these neuronal populations by CNO exhibited prolonged arousal time. Propofol can directly activate the GABA receptors to inhibit the anterior TRN GABAergic neurons and induce general anesthesia. Activation ...
active neurons in the VM send projections to important brain regions that contribute to REM sleep generation and/or maintenance, including the spinal cord [23, 30, 31], the locus coeruleus [20, 21 ...
are selectively wake- active [7, 8]; HA levels positively correlate with wakefulness [9]; H1 receptor inverse agonists promote nonrapid eye movement (NREM) sleep [10–12]; GABAA- receptor -positive allosteric ...
subcortical neurons expressed doublecortin, a marker of migrating cells. The expression of GABA (Calbindin, parvalbumin) and NMDA (NR1, NR2A, NR2B) receptors were also examined. Conclusions: Our results suggest ...
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