The neuronal cannabinoid receptor clone was expressed in Xenopus laevis oocytes as shown by the expression of saturable ( 3 H)WIN 55,212-2 binding sites. Co-expression of the cannabinoid receptor with cRNA coding for the G-protein-gated inwardly rectifying K + channel (GIRK1) resulted in oocytes exhibiting large inward K + currents in response to the cannobinoid agonist WIN 55,212-2. The activation of the potassium current by WIN 55,212-2 was dose-dependent with an EC 50 of 630 nM. These results suggest that activation of inwardly rectifying K + channels may be an additional effector mechanism for brain cannabinoid receptors.
Neuroscience Letters – Elsevier
Published: Feb 17, 1995
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