Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes

Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain... The neuronal cannabinoid receptor clone was expressed in Xenopus laevis oocytes as shown by the expression of saturable ( 3 H)WIN 55,212-2 binding sites. Co-expression of the cannabinoid receptor with cRNA coding for the G-protein-gated inwardly rectifying K + channel (GIRK1) resulted in oocytes exhibiting large inward K + currents in response to the cannobinoid agonist WIN 55,212-2. The activation of the potassium current by WIN 55,212-2 was dose-dependent with an EC 50 of 630 nM. These results suggest that activation of inwardly rectifying K + channels may be an additional effector mechanism for brain cannabinoid receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes

Neuroscience Letters, Volume 186 (2) – Feb 17, 1995

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0304-3940
D.O.I.
10.1016/0304-3940(95)11289-9
Publisher site
See Article on Publisher Site

Abstract

The neuronal cannabinoid receptor clone was expressed in Xenopus laevis oocytes as shown by the expression of saturable ( 3 H)WIN 55,212-2 binding sites. Co-expression of the cannabinoid receptor with cRNA coding for the G-protein-gated inwardly rectifying K + channel (GIRK1) resulted in oocytes exhibiting large inward K + currents in response to the cannobinoid agonist WIN 55,212-2. The activation of the potassium current by WIN 55,212-2 was dose-dependent with an EC 50 of 630 nM. These results suggest that activation of inwardly rectifying K + channels may be an additional effector mechanism for brain cannabinoid receptors.

Journal

Neuroscience LettersElsevier

Published: Feb 17, 1995

References

  • Cannabinoid receptor regulated cyclic AMP accumulation in the rat striatum
    Bidaut-Russell, M.; Howlett, A.C.
  • Cannabinoids modulate potassium current in cultured hippocampal neurons
    Deadwyler, S.A.; Hampson, R.E.; Bennett, B.A.; Edwards, T.A.; Mu, J.; Pacheco, M.A.; Ward, S.J.; Childers, S.R.

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