Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids

Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked... Cannabinoid use is known to disrupt learning and memory in a number of species. cholecystokinin (CCK) release and CCK receptors have been implicated in spatial memory processes in rodents. Rat hippocampal CCK interneurons express cannabinoid 1 receptors (CB1). The CB1 agonist R (+)WIN 55,212–2 (WIN+), at 1 and 10 μmol, strongly inhibited potassium-evoked CCK release from rat hippocampal slices, while the inactive isomer S (−)WIN,55,212–3 (WIN−) had no effect. CCK release from cerebral cortical slices was not altered by WIN+. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids

Neuroscience Letters, Volume 301 (1) – Mar 23, 2001

Loading next page...
 
/lp/elsevier/activation-of-cb1-cannabinoid-receptors-in-rat-hippocampal-slices-X2i75v7n5n
Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Ireland Ltd
ISSN
0304-3940
DOI
10.1016/S0304-3940(01)01591-9
Publisher site
See Article on Publisher Site

Abstract

Cannabinoid use is known to disrupt learning and memory in a number of species. cholecystokinin (CCK) release and CCK receptors have been implicated in spatial memory processes in rodents. Rat hippocampal CCK interneurons express cannabinoid 1 receptors (CB1). The CB1 agonist R (+)WIN 55,212–2 (WIN+), at 1 and 10 μmol, strongly inhibited potassium-evoked CCK release from rat hippocampal slices, while the inactive isomer S (−)WIN,55,212–3 (WIN−) had no effect. CCK release from cerebral cortical slices was not altered by WIN+.

Journal

Neuroscience LettersElsevier

Published: Mar 23, 2001

References

  • The effects of cannabinoids on the brain
    Ameri, A.
  • Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain
    Marsicano, G.; Lutz, B.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off