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ventricular filling and function , and reduced cardiac output. Adenylyl cyclase (AC) expression and activity are reduced in animal models of heart failure. Stimulation of AC can inhibit extracellular matrix ...
, the hearts were used for adenylyl cyclase activity determination, protein quantification, and mRNA level determination. A temporal relationship between the expression of G s α proteins and cardiac hypertrophy ...
changes of cardiac β1‐ and β2‐ARs in stress, but only a few deal with modulation of cardiac β3‐AR. Our aim was to analyze the expression and binding sites of β1‐, β2‐ and β3‐ARs and adenylyl cyclase ...
that activation of AC1 enhances memory formation. Cardiac -directed overexpression of AC6 improves cardiac function and has favourable effects on the failing heart. In these mice no increase in heart rate or left ...
ORIGINAL ARTICLE Adenylyl cyclase type 6 overexpression selectively enhances β-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts ...
AimsIncrease of cardiac cAMP bioavailability and PKA activity through adenylyl - cyclase 8 (AC8) overexpression enhances contractile function in young transgenic mice (AC8TG). Ageing is associated ...
and adenylyl cyclase (AC) by immunoblotting with specific antibodies. A functional status of the AC signaling system was also evaluated. Normal maturation of rat heart was accompanied by increased expression ...
AC6KO, two-way ANOVA with Tukey’s multiple comparison’s test. https://doi.org/10.1371/journal.pone.0218110.g005 PDE3, PDE4 and Gi regulation of adenylyl cyclase activity is consistent with the functional ...
capacity in cardiac myocytes. BRC 559 Basic Res Cardiol 101: 117 – 126 (2006) DOI 10.1007/s00395-005-0559-y ORIGINAL CONTRIBUTION Tong Tang Adenylyl cyclase type V deletion increases N. Chin Lai, David M ...
expression of a photoactivatable adenylyl cyclase (bPAC), that when activated by blue light caused a dose-dependent and time-limited increase in autonomous cardiomyocyte beat rate. Bioelectronic readouts were ...
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