Journal of Cardiothoracic and Vascular Anesthesia 32 (2018) 952–955 Contents lists available at ScienceDirect Journal of Cardiothoracic and Vascular Anesthesia journal homepage: www.jcvaonline.com Case Report Acquired Factor VIII Inhibitor and Cardiopulmonary Bypass n,1 n † Matthias Längin, MD , Mark Konrad, MD , Bruno Reichart, MD, PhD , n n Andreas Bauer, MD , Susanne Lison, MD Department of Anaesthesiology, University Hospital, LMU Munich, Germany Department of Cardiac Surgery, University Hospital, LMU Munich, Germany Key Words: hemophilia; factor VIII inhibitor; coagulopathy; FEIBA; cardiopulmonary bypass ACQUIRED HEMOPHILIA A (AHA) may cause massive hypertension, noninsulin- dependent diabetes mellitus, and bleeding during surgical procedures due to the formation of nicotine abuse. speciﬁc autoantibodies most frequently against coagulation At the time of admission, there were no obvious signs of factor VIII (FVIII), which decrease its activity and plasma cutaneous bleeding, hematemesis, or melena. Standard coagu- half-life. Whereas up to 30% of chronically substituted lation parameters were within normal ranges. Endoscopy did patients with inherited hemophilia A develop inhibitor activity not reveal any signs of intestinal tract bleeding, but multiple during their treatment, the incidence of AHA is extremely low polyps were found and ablated, one showing a local carcinoid 1,2 at 1.5 cases
Journal of Cardiothoracic and Vascular Anesthesia – Elsevier
Published: Apr 1, 2018
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