A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes

A review of specific dietary antioxidants and the effects on biochemical mechanisms related to... Aging is a major risk factor for neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced overproduction of reactive oxygen species (ROS) may give rise to oxidative stress which can induce neuronal damage, ultimately leading to neuronal death by apoptosis or necrosis. A large body of evidence indicates that oxidative stress is involved in the pathogenesis of AD, PD, and ALS. An increasing number of studies show that nutritional antioxidants (especially Vitamin E and polyphenols) can block neuronal death in vitro, and may have therapeutic properties in animal models of neurodegenerative diseases including AD, PD, and ALS. Moreover, clinical data suggest that nutritional antioxidants might exert some protective effect against AD, PD, and ALS. In this paper, the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed. Particular emphasis will be given to the role played by the nuclear transcription factor-κB (NF-κB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-κB function and their relevance in the pathophysiology of neurodegenerative diseases will also be examined. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurobiology of Aging Elsevier

A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes

Loading next page...
 
/lp/elsevier/a-review-of-specific-dietary-antioxidants-and-the-effects-on-aODy1RtOcg
Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Ltd
ISSN
0197-4580
D.O.I.
10.1016/S0197-4580(02)00078-7
Publisher site
See Article on Publisher Site

Abstract

Aging is a major risk factor for neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). An unbalanced overproduction of reactive oxygen species (ROS) may give rise to oxidative stress which can induce neuronal damage, ultimately leading to neuronal death by apoptosis or necrosis. A large body of evidence indicates that oxidative stress is involved in the pathogenesis of AD, PD, and ALS. An increasing number of studies show that nutritional antioxidants (especially Vitamin E and polyphenols) can block neuronal death in vitro, and may have therapeutic properties in animal models of neurodegenerative diseases including AD, PD, and ALS. Moreover, clinical data suggest that nutritional antioxidants might exert some protective effect against AD, PD, and ALS. In this paper, the biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed. Particular emphasis will be given to the role played by the nuclear transcription factor-κB (NF-κB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-κB function and their relevance in the pathophysiology of neurodegenerative diseases will also be examined.

Journal

Neurobiology of AgingElsevier

Published: Sep 1, 2002

References

  • Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress
    Aguirre, T.; Van Den Bosch, L.; Goetshalckx, K.; Tilkin, P.; Mathijs, G.; Cassiman, J.J.
  • Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice
    Andreassen, O.A.; Dedeoglu, A.; Friedlich, A.; Ferrante, K.L.; Hughes, D.; Szabo, C.
  • Mitochondria, free radicals, and neurodegeneration
    Beal, M.F.
  • Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
    Beal, M.F.; Ferrante, R.J.; Browne, S.E.; Matthews, R.T.; Kowall, N.W.; Brown, R.H.
  • Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues
    Cushman, M.; Nagaratham, D.; Burg, D.L.; Geahlen, R.L.
  • Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu, Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis
    Dal Canto, M.; Gurney, M.E.
  • Regulation of gene expression by reactive oxygen
    Dalton, T.P.; Shertzer, H.G.; Puga, A.
  • Tissue injury by reactive oxygen species and the protective effects of flavonoids
    de Groot, H.; Rauen, U.
  • Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
    Dexter, D.T.; Sian, J.; Rose, S.; Hindmarsch, J.G.; Mann, V.M.; Cooper, J.M.
  • Fullerene-based antioxidants and neurodegenerative disorders
    Dugan, L.L.; Lovett, E.G.; Quick, K.L.; Lotharius, J.; Lin, T.T.; O’Malley, K.L.
  • Lyophilized red wine administration prolongs survival in an animal model of amyotrophic lateral sclerosis
    Esposito, E.; Rossi, C.; Amodio, R.; Di Castelnuovo, A.; Bendotti, C.; Rotondo, T.
  • Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS
    Hall, E.D.; Andrus, P.K.; Oostveen, J.A.; Fleck, T.J.; Gurney, M.E.
  • Generation of reactive oxygen species, release of l -glutamate and activation of caspases are required for oxygen-induced apoptosis of embryonic hippocampal neurons in culture
    Ishikawa, Y.; Satoh, T.; Enokido, Y.; Nishio, C.; Ikeuchi, T.; Hatanaka, H.
  • Vitamin E: interactions with free radicals and ascorbate
    McCay, P.B.
  • Neurotoxicity of levodopa on catecholamine-rich neurons
    Mena, M.A.; Pardo, B.; Casarejos, M.J.; Fahn, S.; de Yebenes, J.G.
  • Apoptosis in neural development and disease
    Nijhawan, D.; Honarpour, N.; Wang, X.
  • Moderate wine consumption is associated with decreased odds of developing age-related macular degeneration in NHANES-1
    Obisesan, T.O.; Hirsh, R.; Kosoko, O.; Carlson, L.; Parrott, M.
  • The red wine phenolics trans -resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease
    Pace-Asciak, C.R.; Hahn, S.; Diamandis, E.P.; Soleas, G.; Goldberg, D.M.
  • Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients
    Pedersen, W.A.; Fu, W.; Keller, J.N.; Markesbery, W.R.; Appel, S.; Smith, R.G.
  • Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics
    Poduslo, J.F.; Whelan, S.L.; Curran, G.L.; Wengenack, T.M.
  • Superoxide dismutase, catalase, and glutathione peroxidase activities in copper/zinc-superoxide dismutase transgenic mice
    Przedborski, S.; Jackson-Lewis, V.; Kostic, V.; Carlson, E.; Epstein, C.J.; Cadet, J.L.
  • Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis
    Reinholz, M.M.; Merkle, C.M.; Poduslo, J.F.
  • Transition metals, ferritin, glutathione, and ascorbic acid in Parkinsonian brains
    Riederer, P.; Sofic, E.; Rausch, W.-D.; Schmidt, B.; Reynolds, G.P.; Jellinger, K.
  • Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants
    Salah, N.; Miller, N.J.; Paganga, G.; Tijburg, L.; Bolwell, G.P.; Rice-Evans, C.
  • DATATOP: a decade of neuroprotective inquiry
    Shoulson, I.
  • Oxidative stress in neurodegenerative diseases
    Simonian, N.A.; Coyle, J.T.
  • Biochemical events in the development of Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    Singer, T.P.; Castagnoli, N.; Ramsay, R.R.; Trevor, A.J.
  • Amyotrophic lateral sclerosis. Part 1. Clinical features, pathology, and ethical issues in management
    Tandan, R.; Bradley, W.G.
  • Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans -resveratrol in rats
    Virgili, M.; Contestabile, A.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off