A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3

A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3 •In 13 lung cancer cell lines, with qPCR BRS-3mRNA was expressed in 92%, GRPR and NMBR in 85%.•In 54% of lung cancer cell lines BRS-3mRNA was present in larger amounts than GRPR/NMBR.•Positive BRS-3 cell lines in 100% showed either/or MAPK/PLC activation with a BRS-3 agonist.•Selective BRS-3 agonists stimulated growth of BRS-3 positive lung cancer cell lines.•In 54% of cell-lines BRS-3 agonists stimulated growth was mediated by EGFR transactivation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3

Loading next page...
 
/lp/elsevier/a-possible-new-target-in-lung-cancer-cells-the-orphan-receptor-fGciwzmJcp
Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0196-9781
D.O.I.
10.1016/j.peptides.2018.01.016
Publisher site
See Article on Publisher Site

Abstract

•In 13 lung cancer cell lines, with qPCR BRS-3mRNA was expressed in 92%, GRPR and NMBR in 85%.•In 54% of lung cancer cell lines BRS-3mRNA was present in larger amounts than GRPR/NMBR.•Positive BRS-3 cell lines in 100% showed either/or MAPK/PLC activation with a BRS-3 agonist.•Selective BRS-3 agonists stimulated growth of BRS-3 positive lung cancer cell lines.•In 54% of cell-lines BRS-3 agonists stimulated growth was mediated by EGFR transactivation.

Journal

PeptidesElsevier

Published: Mar 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off