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A polymorphism of the tryptophan hydroxylase gene is not associated with idiopathic recurrent miscarriage.

Objective: Immunologic factors are believed to play a major etiologic role in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the relation between IRM and a polymorphism in intron 7 of the tryptophan hydroxylase (TPH) gene, an immunologic modulator on the placental level. Design: Prospective case control study. Materials/Methods: We investigated 125 women with a history of 3 or more consecutive pregnancy losses before 20 weeks gestation and 137 healthy controls with at least 2 live births and no history of pregnancy loss. Peripheral venous puncture, DNA extraction, and polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) analysis were used to genotype women for the presence of the A218C polymorphism of the TPH gene. Results: Allele frequencies among women with IRM and controls were 32.4% and 38.7%, respectively, for allele A (wild type) and 67.6% and 61.3%, respectively, for allele C (mutant). No association between the presence of allele C and IRM was found (P = .3, odds ratio [OR] 1.31; Confidence Interval [CI] 0.93 to 1.87). Genotype frequencies were also not significantly different between the study group (C/C: 44.8%, A/C: 45.6%, A/A: 9.6%) and the control group (C/C: 37.2%, A/C: 48.2%, A/A: 14.6%; P = .2). Between women with primary and secondary IRM, no statistically significant differences with respect to allelic frequencies were observed (63% vs. 62% for allele C and 31% vs. 38% for allele A; P = .3). Conclusions: This is the first report on a TPH gene polymorphism among women with IRM, demonstrating that the investigated A218C polymorphism in intron 7 is not associated with IRM in a Caucasian population.</P> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fertility and Sterility Elsevier
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