“Whoa! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free

A polymorphism of the tryptophan hydroxylase gene is not associated with idiopathic recurrent miscarriage.

Objective: Immunologic factors are believed to play a major etiologic role in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the relation between IRM and a polymorphism in intron 7 of the tryptophan hydroxylase (TPH) gene, an immunologic modulator on the placental level. Design: Prospective case control study. Materials/Methods: We investigated 125 women with a history of 3 or more consecutive pregnancy losses before 20 weeks gestation and 137 healthy controls with at least 2 live births and no history of pregnancy loss. Peripheral venous puncture, DNA extraction, and polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) analysis were used to genotype women for the presence of the A218C polymorphism of the TPH gene. Results: Allele frequencies among women with IRM and controls were 32.4% and 38.7%, respectively, for allele A (wild type) and 67.6% and 61.3%, respectively, for allele C (mutant). No association between the presence of allele C and IRM was found (P = .3, odds ratio [OR] 1.31; Confidence Interval [CI] 0.93 to 1.87). Genotype frequencies were also not significantly different between the study group (C/C: 44.8%, A/C: 45.6%, A/A: 9.6%) and the control group (C/C: 37.2%, A/C: 48.2%, A/A: 14.6%; P = .2). Between women with primary and secondary IRM, no statistically significant differences with respect to allelic frequencies were observed (63% vs. 62% for allele C and 31% vs. 38% for allele A; P = .3). Conclusions: This is the first report on a TPH gene polymorphism among women with IRM, demonstrating that the investigated A218C polymorphism in intron 7 is not associated with IRM in a Caucasian population.</P> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fertility and Sterility Elsevier
Loading next page...
1 Page

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for just $40/month

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.