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investigation. We performed this study to evaluate the efficacy of sirolimus -eluting vascular grafts in preventing stenosis and to compare the effectiveness of sirolimus -coated grafts with that of paclitaxel ...
to the site of stenosis resulting in high local concentrations with minimal systemic toxicity [ 10 ]. Experimental in vitro studies have demonstrated the efficacy of sirolimus and paclitaxel eluted from stents ...
, and the thrombosis rate was 0.37/patient-year. Conclusions. Perivascular implantation of the Coll-R during graft surgery safely delivered sirolimus to the vascular wall. Systemic sirolimus levels were sub-therapeutic ...
., Langer , M., Betz , E. ( 1998 ) Effect on intimal hyperplasia of dexamethasone released from coated metal stents compared with non-coated stents in canine femoral arteries . Cardiovasc. Intervent. Radiol ...
perivascular delivery of paclitaxel. Kidney Int 2004 ; 66 : 2061 –2069 Google Scholar 14 Rotmans JI, Pattynama PM, Verhagen HJ et al . Sirolimus -eluting stents to abolish intimal hyperplasia and improve flow ...
- release drug delivery systems is rapidly expanding. Another relatively new field with exciting developments is vascular tissue engineering. Vascular tissue engineering enables creation of a diameter ...
, which determines a disproportionate uptake of circulating lipids.44,45 Neo-atherosclerosis is less frequent in BMS when compared with DES, and the drugs, as paclitaxel, sirolimus , or tacrolimus, released ...
a sirolimus -eluting stent that inhibits the proliferation of lymphocytes and SMCs has recently been shown to be promising [4], no effective therapy to prevent restenosis after non-stent angioplasty has yet been ...
. Analysis of the perivascular space was therefore generally excluded in this study. 4.4 Results of this study There are two studies about retinoids for restenosis in literature using systemic atRA delivery ...
, blocking the proteasome system reduced intimal hyperplasia,7,8 showing that inflammation contributes significantly to intimal hyperplasia. The final common pathway of these mechanisms is the initiation ...
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