A novel neurotensin analog blocks cocaine- and d -amphetamine-induced hyperactivity

A novel neurotensin analog blocks cocaine- and d -amphetamine-induced hyperactivity Neurotensin is a tridecapeptide that exhibits selective anatomic and neurochemical interactions with dopaminergic systems. Since dopaminergic neurotransmission underlies many of the behavioral properties of psychostimulants, and since neurotensin has been implicated in modulating dopaminergic neurotransmitter systems, we tested the effect of our novel neurotensin analog, NT69L ( N -methyl-Arg 8 , l -Lys 9 , l - neo -Trp 11 ,tert-Leu 12 )neurotensin-(8-13)), on hyperactivity caused by cocaine and d -amphetamine. Previously, we showed that NT69L reduces body temperature, blocks apomorphine-induced climbing, and haloperidol-induced catalepsy. In this study, NT69L blocked the hyperactivity induced by both cocaine and d -amphetamine administered at three different doses each, when this peptide was injected intraperitoneally. These results provide further evidence for the involvement of the neurotensin system in some of the behavioral properties of psychostimulants and suggest that NT69L may find clinical application in patients who abuse this class of compounds. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

A novel neurotensin analog blocks cocaine- and d -amphetamine-induced hyperactivity

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(01)01197-9
Publisher site
See Article on Publisher Site

Abstract

Neurotensin is a tridecapeptide that exhibits selective anatomic and neurochemical interactions with dopaminergic systems. Since dopaminergic neurotransmission underlies many of the behavioral properties of psychostimulants, and since neurotensin has been implicated in modulating dopaminergic neurotransmitter systems, we tested the effect of our novel neurotensin analog, NT69L ( N -methyl-Arg 8 , l -Lys 9 , l - neo -Trp 11 ,tert-Leu 12 )neurotensin-(8-13)), on hyperactivity caused by cocaine and d -amphetamine. Previously, we showed that NT69L reduces body temperature, blocks apomorphine-induced climbing, and haloperidol-induced catalepsy. In this study, NT69L blocked the hyperactivity induced by both cocaine and d -amphetamine administered at three different doses each, when this peptide was injected intraperitoneally. These results provide further evidence for the involvement of the neurotensin system in some of the behavioral properties of psychostimulants and suggest that NT69L may find clinical application in patients who abuse this class of compounds.

Journal

European Journal of PharmacologyElsevier

Published: Aug 24, 2001

References

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