A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa

A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa Phylogenetic analysis of the 5′ non-coding region (5′NCR) sequences has demonstrated that GB virus C/hepatitis G virus (GBV-C/HGV) can be separated into three major groups that correlate with the geographic origin of the isolate. Sequence analysis of the 5′NCR of 54 GBV-C/HGV isolates from 31 blood donors, 11 haemodialysis patients and 12 patients with chronic liver disease suggests the presence of a new variant of GBV-C/HGV in the province of KwaZulu Natal, South Africa. Eleven isolates grouped as group 1 variants (bootstrap support, 90%) found predominantly in West and Central Africa, a further six isolates grouped as group 2 variants (bootstrap support, 58%) found in Europe and North America; five of which grouped as 2a (bootstrap support, 91%) and one as 2b (bootstrap support, 87%), the latter also includes isolates from Japan, East Africa and Pakistan. Although the remaining 37 GBV-C/HGV isolates were more closely related to group 1 variants (bootstrap support, 90%), they formed a cluster, which was distinct from all other known GBV-C/HGV sequences. None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science B.V.
ISSN
0168-1702
D.O.I.
10.1016/S0168-1702(99)00090-8
Publisher site
See Article on Publisher Site

Abstract

Phylogenetic analysis of the 5′ non-coding region (5′NCR) sequences has demonstrated that GB virus C/hepatitis G virus (GBV-C/HGV) can be separated into three major groups that correlate with the geographic origin of the isolate. Sequence analysis of the 5′NCR of 54 GBV-C/HGV isolates from 31 blood donors, 11 haemodialysis patients and 12 patients with chronic liver disease suggests the presence of a new variant of GBV-C/HGV in the province of KwaZulu Natal, South Africa. Eleven isolates grouped as group 1 variants (bootstrap support, 90%) found predominantly in West and Central Africa, a further six isolates grouped as group 2 variants (bootstrap support, 58%) found in Europe and North America; five of which grouped as 2a (bootstrap support, 91%) and one as 2b (bootstrap support, 87%), the latter also includes isolates from Japan, East Africa and Pakistan. Although the remaining 37 GBV-C/HGV isolates were more closely related to group 1 variants (bootstrap support, 90%), they formed a cluster, which was distinct from all other known GBV-C/HGV sequences. None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal: groups 1, 2 and a new variant, which is distinct from other African isolates.

Journal

Virus ResearchElsevier

Published: Nov 1, 1999

References

  • Isolation of a GB virus related genome from a chimpanzee
    Birkenmeyer, L.G.; Desai, M.D.; Muerhoff, A.S.; Leary, T.P.; Simons, J.N.; Montes, C.C.; Mushahwar, I.K.
  • Detection of GBV-C RNA in patients with non-A–E fulminant hepatitis by reverse transcription polymerase chain reaction
    Kanda, T.; Yokosuka, O.; Ehata, T.; Maru, Y.; Imazeki, F.; Saisho, H.; Shiratori, Y.; Omata, M.
  • Detection of GB Virus C by RT-PCR LCx system
    Marshall, R.L.; Cockerill, J.; Friedman, P.; Hayden, M.; Hodges, S.; Holas, C.; Jennings, C.; Jou, C.K.; Kratochvil, J.; Laffer, T.; Lewis, N.; Scheffel, C.; Traylor, D.; Wang, L.; Solomon, N.
  • GB virus C/hepatitis G virus infection in KwaZulu Natal, South Africa
    Sathar, M.A.; Soni, P.N.; Naicker, S.; Conradie, J.; Lockhat, F.; Gouws, E.
  • High prevalence of GBV-C hepatitis G virus infection in a rural South African population
    Tucker, T.J.; Louw, S.J.; Robson, S.C.; Isaacs, S.; Kirsch, R.
  • Infection with GB virus C (GBV-C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia
    Tsuda, F.; Hadiwanddowo, S.; Sawada, N.; Fukuda, M.; Tanaka, T.; Okamoto, H.; Miyakawa, Y.; Mayumi, M.

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