Article history: The partial or Hansen solubility parameters (HSP) are important properties of the various substances Received 8 December 2011 and very useful tools for the selection of their solvents or the prediction of their behaviour in numerous Received in revised form 1 January 2012 applications. Their design and evaluation relies on the basic rule of “similarity matching” for solubility. Accepted 2 January 2012 The present work attempts to enhance the capacity of HSPs by incorporating into their evaluation the Available online 9 January 2012 other basic rule of solubility, namely, the rule of “complementarity matching”. This is done in a simple and straightforward manner by splitting the hydrogen bonding HSP into its acidic or proton donor component Keywords: and its basic or proton acceptor one. The splitting is based on the third -moments of the screening charge Partial solubility parameter distributions or sigma proﬁles of the quantum-mechanics based COSMO-RS theory. The whole develop- Hydrogen-bonding ment and application does not involve any sophisticated calculations or any strong speciﬁc background. COSMO-RS theory The new method has been applied to a variety of solubility data for systems of pharmaceutical interest in Group-contribution method order to verify the signiﬁcant improvement over the
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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