•A luciferase immunoprecipitation system (LIPS) assay was developed for the detection of antibodies against human norovirus (HuNoV).•The LIPS assay detected higher end-point titers in serum than an ELISA.•The LIPS assay allowed comparative analyses of the immune response to individual capsid protein domains.•A competitive LIPS assay proved useful in further assessment of the antibody specificity in complex polyclonal sera.
Journal of Virological Methods – Elsevier
Published: Oct 1, 2017
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