A Luciferase Immunoprecipitation System (LIPS) assay for profiling human norovirus antibodies

A Luciferase Immunoprecipitation System (LIPS) assay for profiling human norovirus antibodies •A luciferase immunoprecipitation system (LIPS) assay was developed for the detection of antibodies against human norovirus (HuNoV).•The LIPS assay detected higher end-point titers in serum than an ELISA.•The LIPS assay allowed comparative analyses of the immune response to individual capsid protein domains.•A competitive LIPS assay proved useful in further assessment of the antibody specificity in complex polyclonal sera. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Virological Methods Elsevier

A Luciferase Immunoprecipitation System (LIPS) assay for profiling human norovirus antibodies

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
0166-0934
eISSN
1879-0984
D.O.I.
10.1016/j.jviromet.2017.06.017
Publisher site
See Article on Publisher Site

Abstract

•A luciferase immunoprecipitation system (LIPS) assay was developed for the detection of antibodies against human norovirus (HuNoV).•The LIPS assay detected higher end-point titers in serum than an ELISA.•The LIPS assay allowed comparative analyses of the immune response to individual capsid protein domains.•A competitive LIPS assay proved useful in further assessment of the antibody specificity in complex polyclonal sera.

Journal

Journal of Virological MethodsElsevier

Published: Oct 1, 2017

References

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