A graphene quantum dot-based method for the highly sensitive and selective fluorescence turn on detection of biothiols

A graphene quantum dot-based method for the highly sensitive and selective fluorescence turn on... 1 Introduction</h5> Biothiol compounds such as glutathione, cysteine, and homocysteine play important roles in maintaining proper body functions. Glutathione (GSH) is a thiol-containing tripeptide (γ-glutamyl–cysteinyl–glycine). GSH is widely distributed in almost every cell [1] . It helps to maintain the normal functions of the immune system, and it is an essential endogenous antioxidant which has often been used against toxins and free radicals [2] . Abnormal GSH levels have been used for disease diagnosis and clinical therapies [3,4] . Cysteine (Cys) is one of the twenty amino acids required for protein biosynthesis. It is also a precursor required for the biosynthesis of GSH. The thiol functional group of Cys could be easily oxidized to give a disulfide bridge, which plays essential structural roles in many proteins [5] . Elevated levels of Cys have been associated with neurotoxicity [6] . Homocysteine (Hcy) is an amino acid that differs from cysteine by an additional methylene bridge (–CH 2 –). The intracellular concentration of Hcy under normal conditions is kept low [7] . Elevated levels of Hcy are associated with Alzheimer's disease, cardiovascular diseases, and osteoporosis [8] . Therefore, quantitative detection of biothiol compounds is of great importance for human health.</P>Various http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Talanta Elsevier

A graphene quantum dot-based method for the highly sensitive and selective fluorescence turn on detection of biothiols

Talanta, Volume 119 – Feb 15, 2014

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Publisher
Elsevier
Copyright
Copyright © 2013 Elsevier B.V.
ISSN
0039-9140
eISSN
1873-3573
D.O.I.
10.1016/j.talanta.2013.11.065
Publisher site
See Article on Publisher Site

Abstract

1 Introduction</h5> Biothiol compounds such as glutathione, cysteine, and homocysteine play important roles in maintaining proper body functions. Glutathione (GSH) is a thiol-containing tripeptide (γ-glutamyl–cysteinyl–glycine). GSH is widely distributed in almost every cell [1] . It helps to maintain the normal functions of the immune system, and it is an essential endogenous antioxidant which has often been used against toxins and free radicals [2] . Abnormal GSH levels have been used for disease diagnosis and clinical therapies [3,4] . Cysteine (Cys) is one of the twenty amino acids required for protein biosynthesis. It is also a precursor required for the biosynthesis of GSH. The thiol functional group of Cys could be easily oxidized to give a disulfide bridge, which plays essential structural roles in many proteins [5] . Elevated levels of Cys have been associated with neurotoxicity [6] . Homocysteine (Hcy) is an amino acid that differs from cysteine by an additional methylene bridge (–CH 2 –). The intracellular concentration of Hcy under normal conditions is kept low [7] . Elevated levels of Hcy are associated with Alzheimer's disease, cardiovascular diseases, and osteoporosis [8] . Therefore, quantitative detection of biothiol compounds is of great importance for human health.</P>Various

Journal

TalantaElsevier

Published: Feb 15, 2014

References

  • Chem. Commun.
    Zhu, S.; Tang, S.; Zhang, J.; Yang, B.
  • Chem. Commun.
    Shen, J.; Zhu, Y.; Yang, X.; Li, C.

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