1 Introduction</h5> Biothiol compounds such as glutathione, cysteine, and homocysteine play important roles in maintaining proper body functions. Glutathione (GSH) is a thiol-containing tripeptide (γ-glutamyl–cysteinyl–glycine). GSH is widely distributed in almost every cell  . It helps to maintain the normal functions of the immune system, and it is an essential endogenous antioxidant which has often been used against toxins and free radicals  . Abnormal GSH levels have been used for disease diagnosis and clinical therapies [3,4] . Cysteine (Cys) is one of the twenty amino acids required for protein biosynthesis. It is also a precursor required for the biosynthesis of GSH. The thiol functional group of Cys could be easily oxidized to give a disulfide bridge, which plays essential structural roles in many proteins  . Elevated levels of Cys have been associated with neurotoxicity  . Homocysteine (Hcy) is an amino acid that differs from cysteine by an additional methylene bridge (–CH 2 –). The intracellular concentration of Hcy under normal conditions is kept low  . Elevated levels of Hcy are associated with Alzheimer's disease, cardiovascular diseases, and osteoporosis  . Therefore, quantitative detection of biothiol compounds is of great importance for human health.</P>Various
Talanta – Elsevier
Published: Feb 15, 2014
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