1 Introduction</h5> Glutathione (GSH), a thiol-containing tripeptide (γ-Glu–Cys–Gly), plays key roles in biological systems and serves many cellular functions such as intracellular signal transduction, maintenance of intracellular redox activities, gene regulation, and xenobiotic metabolism ( Dalton et al., 1999; Kanzok et al., 2000; Krauth-Siegel et al., 2005; Meister, 1988; Schirmer et al., 1995 ). The concentration of GSH ranges from millimolar inside the cells of all tissues and organs to micromolar in plasma and other biological fluids such as saliva, cerebrospinal fluid, and urine ( Pastore et al., 2003 ). Abnormal levels of cellular GSH have been linked to a number of diseases, such as leukocyte loss, psoriasis, liver damage, cancer, aging, heart problems, and other ailments ( Lu, 2009; Townsend et al., 2003 ). A decrease in GSH is a risk factor for chronic diseases that may be used to monitor the severity and progress of the diseases ( Lang et al., 2000 ). Because of its important biological roles, research interests to develop efficient methods for the monitoring and determination of GSH under physiological conditions are growing unabated ( Chen et al., 2010a; Monostori et al., 2009 ). In general, the conventional methods for determining GSH
Biosensors and Bioelectronics – Elsevier
Published: Jun 15, 2014
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