Acta Biomaterialia 71 (2018) 72–85 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article A continuum of mineralization from human renal pyramid to stones on stems a b b b a a Benjamin A. Sherer , Ling Chen , Misun Kang , Alex R. Shimotake , Scott V. Wiener , Tom Chi , a a,b,⇑,1 Marshall L. Stoller , Sunita P. Ho Department of Urology, University of California San Francisco, San Francisco, CA 94143, United States Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California San Francisco, San Francisco, CA 94143, United States ar ti c l e i nf o ab stra ct Article history: The development of new modalities for kidney stone prevention rests upon understanding the progres- Received 24 October 2017 sion of mineralization within the renal pyramid. The progression from small foci of mineralized volumes Received in revised form 21 December 2017 within the renal pyramid to larger interstitial plaques that ultimately lead into clinically detectable Accepted 25 January 2018 calcium-based stones on calcium phosphate stems will be presented through correlative microscopy Available online 9 February 2018 approach. High resolution X-ray computed tomography (micro-XCT), electron
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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