March 2018 ORIGINAL ARTICLES 16. Ramírez-Vélez R, Morales O, Peña-Ibagon JC, Palacios-López A, Prieto- weight, height velocity, weight velocity, and stages of puberty. Arch Dis Benavides DH, Vivas A, et al. Normative reference values for handgrip Child 1976;51:170-9. strength in Colombian schoolchildren: the FUPRECOL study. J Strength 21. Hanley JA, McNeil BJ. A method of comparing the areas under receiver Cond Res 2017;31:217-26. operating characteristic curves derived from the same cases. Radiology 17. Ramírez-Vélez R, Rodrigues-Bezerra D, Correa-Bautista JE, Izquierdo M, 1983;148:839-43. Lobelo F. Reliability of health-related physical ﬁtness tests among Co- 22. Sasayama K, Ochi E, Adachi M. Importance of both fatness and aerobic lombian children and adolescents: the FUPRECOL study. PLoS One ﬁtness on metabolic syndrome risk in Japanese children. PLoS One 2015;10:e0140875. 2015;10:e0127400. 18. Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, et al. 23. Welk GJ, Laurson KR, Eisenmann JC, Cureton KJ. Development of youth The metabolic syndrome in children and adolescents: an IDF consensus aerobic-capacity standards using receiver operating characteristic curves. report. Pediatr Diabetes 2007;8:299-306. Am J Prev Med 2011;41(4 Suppl 2):S111-6. 19. de Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai 24. Ruiz JR, Cavero-Redondo I, Ortega FB, Welk GJ, Andersen LB, Martinez- N. Prevalence of the metabolic syndrome in American adolescents: ﬁnd- Vizcaino V. Cardiorespiratory ﬁtness cut points to avoid cardiovascular ings from the Third National Health and Nutrition Examination Survey. disease risk in children and adolescents; what level of ﬁtness should raise Circulation 2004;110:2494-7. a red ﬂag? A systematic review and meta-analysis. Br J Sports Med 20. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, 2016;50:1451-8. Successful Treatment of Juvenile Hemangiomas with Prednisone Fost NC, Esterly NB. J Pediatr 1968;72:351-7. nfantile hemangioma, the most common infantile soft tissue tumor, has a prevalence of 4%-5%, and although un- I complicated infantile hemangioma can be followed clinically while awaiting involution, up to 15% may be associ- ated with functional impairment, tissue destruction, or permanent disﬁgurement which necessitates therapy. In 1968, Fost and Esterly reported in The Journal 6 patients with severe infantile hemangioma who were treated with predni- sone, with regression noted in 5. Their patients had complications including ulceration, external auditory canal com- pression, periorbital involvement/proptosis, and subglottic involvement necessitating tracheostomy. Oral prednisone was administered at 20-30 mg daily for 2-16 weeks, and the authors noted marked improvement in 5 patients, with mild growth retardation in one as the only complication. Following up on preliminary observations by Zarem and Edgerton, Fost and Esterly’s ﬁndings helped foster the adoption of corticosteroids as ﬁrst-line treatment for infantile hemangioma. They remained the mainstay of therapy for 4 decades, until the serendipitous discovery in 2008 of propranolol’s effects against infantile hemangioma altered this paradigm. Leaute-Labreze et al reported 2 infants with massive infantile hemangioma treated with propranolol (for cardiac indications) with marked improvement, and 9 others with severe infantile hemangioma who were sub- sequently treated prospectively. A randomized trial of propranolol conﬁrmed its efﬁcacy in infantile hemangioma therapy, and in 2014, the US Food and Drug Administration approved oral propranolol hydrochloride solution for this indi- cation. Propranolol is now considered ﬁrst-line therapy for complicated infantile hemangioma. This small case series substantiated a relatively well-tolerated and effective treatment for complicated infantile hem- angioma and was a signiﬁcant contribution to the period literature. Their report, and the recent discovery and vali- dation of propranolol’s effects against infantile hemangioma, remind us of the potential beneﬁts to our patients of academic curiosity, scientiﬁc validation, and scholarly dissemination. Anthony J. Mancini,MD Division of Dermatology Ann and Robert H. Lurie Children’s Hospital of Chicago Chicago, Illinois Dr Nancy Esterly passed away on October 8, 2017. She was a giant in the ﬁeld, often referred to as the “mother of pedi- atric dermatology”, and helped establish our journal, Pediatric Dermatology. The epitome of an academic scholar, savvy clinician, and extraordinary mentor, Dr Esterly’s legacy continues to inspire, and will do so for generations to come. References 1. Zarem HA, Edgerton MT. Induced resolution of cavernous hemangiomas following prednisolone therapy. Plast Reconstr Surg 1967;39:76-83. 2. Leaute-Labreze C, de la Roque ED, Hubiche T, Boralevi F, Thambo JB, Taieb A. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008;358:2649-51. 3. Leaute-Labreze C, Hoeger P, Mazereeuw-Hautier J, Guibaud L, Baselga E, Posiunas G, et al. A randomized, controlled trial of oral propranolol in infantile hemangioma. N Engl J Med 2015;372:735-46. Comparison of Different Maximal Oxygen Uptake Equations to Discriminate the Cardiometabolic Risk in Children and Adolescents
The Journal of Pediatrics – Elsevier
Published: Mar 1, 2018
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