THE JOURNAL OF PEDIATRICS www.jpeds.com Volume 194 46. Trautwein C, Friedman SL, Schuppan D, Pinzani M. Hepatic ﬁbrosis: 51. Wree A, Schlattjan M, Bechmann LP, Claudel T, Sowa JP, Stojakovic T, concept to treatment. J Hepatol 2015;62:S15-24. et al. Adipocyte cell size, free fatty acids and apolipoproteins are associ- 47. Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue ated with non-alcoholic liver injury progression in severely obese pa- Z, et al. Autophagy releases lipid that promotes ﬁbrogenesis by activated tients. Metabolism 2014;63:1542-52. hepatic stellate cells in mice and in human tissues. Gastroenterology 52. D’Incao RB, Tovo CV, Mattevi VS, Borges DO, Ulbrich JM, Coral GP, 2012;142:938-46. et al. Adipokine levels versus hepatic histopathology in bariatric surgery 48. Thoen LF, Guimaraes EL, Dolle L, Mannaerts I, Najimi M, Sokal E, et al. patients. Obes Surg 2017;27:2151-8. A role for autophagy during hepatic stellate cell activation. J Hepatol 53. Chawla A, Nguyen KD, Goh YP. Macrophage-mediated inﬂammation in 2011;55:1353-60. metabolic disease. Nat Rev Immunol 2011;11:738-49. 49. Felipo V, Urios A, Garcia-Torres ML, El Mlili N, del Olmo JA, Civera M, 54. Stanton MC, Chen SC, Jackson JV, Rojas-Triana A, Kinsley D, Cui L, et al. et al. Alterations in adipocytokines and cGMP homeostasis in morbid Inﬂammatory Signals shift from adipose to liver during high fat feeding obesity patients reverse after bariatric surgery. Obesity (Silver Spring) and inﬂuence the development of steatohepatitis in mice. J Inﬂamm (Lond) 2013;21:229-37. 2011;8:8. 50. Harrison SA, Fecht W, Brunt EM, Neuschwander-Tetri BA. Orlistat for 55. Meex RCR, Watt MJ. Hepatokines: linking nonalcoholic fatty liver overweight subjects with nonalcoholic steatohepatitis: a randomized, pro- disease and insulin resistance. Nat Rev Endocrinol 2017;13:509- spective trial. Hepatology 2009;49:80-6. 20. Detailing Ipecac; Report on the Committee on Poison Control, Rocky Mountain Pediatric Society Helfer R, Fleischaker G, Huhn L. J Pediatr 1967;71:895-96 or the general practitioner and pediatrician, it is common to receive daily visits from pharmaceutical sales F representatives (PSRs; formerly known as detailmen or detailpersons). With long ofﬁce hours and burnout, practitioners have little time to keep up with all the evidence published in every journal, and many of them rely solely on what the PSRs feed them during their visits. However, the evidence provided by the PSRs must be reliable, given that physicians will not have time to verify every detail of information from the laminated brochures with pop-up images, small lettering, and long tables with series of numbers, percentages, and P values. Although not ill-intended, 50 years ago Helfer et al and Eli Lilly and Company launched what today would be considered a misinformation campaign by touting the beneﬁts of ipecac for managing acutely poisoned patients. The information available at that time recommended the use of ipecac, to the point of suggesting that it be placed in the homes of all preschool children. The response to this campaign was positive, as demonstrated by an increase in the percentage of physicians who used ipecac, had ipecac available in their ofﬁces, and recommended ipecac use at home. The 2004 American Academy of Clinical Toxicology/European Association of Poisons Centres and Clinical Toxi- cologists position paper and its 2013 update established that the routine use of ipecac should be stopped, because the risks outweigh its beneﬁts. The same position paper recommended that physicians and parents discard any ipecac syrup bottle, and that ipecac should not be used routinely in emergency rooms. Pedro Lennon Sáenz Chávez,PhD Pharmacology and Toxicology Department Faculty of Medicine Autonomous University of Nuevo León Monterrey, Mexico References 1. Collete BA, Thomas MS. Pharmaceutical industry-sponsored meals and physician prescribing patterns for Medicare beneﬁciaries. JAMA Intern Med 2016;176:1114-10. 2. Vale JA, Kulig K, American Academy of Clinical Toxicology, European Association of Poisons Centres and Clinical Toxicologists. Position paper: ipecac syrup. J Toxicol Clin Toxicol 2004;42:133-43. 3. American Academy of Pediatrics Committee on Injury, Violence, and Poison Prevention. Poison treatment in the home. Pediatrics 2003;112:1182- Nobili et al
The Journal of Pediatrics – Elsevier
Published: Mar 1, 2018
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