5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice

5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice •The convulsive potential of cefepime was studied via an electroconvulsive shock test.•The effect of 5-FU on neurotoxic effects of cefepime in a PTZ-kindled mouse model was investigated.•Cefepime exacerbated early-onset convulsions in PTZ-kindled mice treated with 5-FU.•Cefepime subsequently induced delayed-onset convulsive status epilepticus.•5-FU treatment increased the risk of the neurotoxic side effects of cefepime. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Epilepsy Research Elsevier

5-Fluorouracil exacerbates cefepime-induced convulsions in pentylenetetrazol-kindled mice

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Publisher
Elsevier
Copyright
Copyright © 2019 Elsevier B.V.
ISSN
0920-1211
DOI
10.1016/j.eplepsyres.2019.106195
Publisher site
See Article on Publisher Site

Abstract

•The convulsive potential of cefepime was studied via an electroconvulsive shock test.•The effect of 5-FU on neurotoxic effects of cefepime in a PTZ-kindled mouse model was investigated.•Cefepime exacerbated early-onset convulsions in PTZ-kindled mice treated with 5-FU.•Cefepime subsequently induced delayed-onset convulsive status epilepticus.•5-FU treatment increased the risk of the neurotoxic side effects of cefepime.

Journal

Epilepsy ResearchElsevier

Published: Nov 1, 2019

References

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