Acta Biomaterialia 71 (2018) 96–107 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article 3D-printed IFN-c-loading calcium silicate-b-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone a,1 a,1 a a b c a,⇑ Tao Li , Mingzheng Peng , Zezheng Yang , Xiaojun Zhou , Yuan Deng , Chuan Jiang , Ming Xiao , a,⇑ Jinwu Wang Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital Afﬁliated Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, 1804 Huashan Rd, Shanghai 200030, China Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 west yanjiang Rd, Guangzhou 510120, China ar ti c l e i nf o ab stra ct Article history: To promote vascularization of tissue-engineered bone, IFN-c polarizing macrophages to M1 was loaded Received 8 October 2017 on 5% calcium silicate/b-tricalcium phosphate (CaSiO -b-TCP) scaffolds. IFN-c and Si released from the Received in revised form 4 March 2018 scaffold were designed to polarize M1 and M2 macrophages, respectively. b-TCP, CaSiO -b-TCP, and Accepted 5
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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