Neuropharmacology Vol. 34, No. 2, pp. 191-203, 1995 002%3908(94)00144-C Copyright 0 1995 Elsevier Science Ltd Printed in Great Britain. All rights reserved 002%3908/95 $9.50 + 0.00 * Department of Psychology and Neuroscience Program, 31 Townshend Hall, The Ohio State University, Columbus, OH 43210, U.S.A. (Accepted 10 October 1994) Summary-A repeated sessions, in vivo microdialysis design was used to determine the Dl- and DZlike receptor modulation of in intact adult rats and those depleted of DA on postnatal Day 3. Systemic administration of the Dl-like agonist SKF 38393 (1 .O or 10.0 mg/kg, or the DZlike antagonist clebopride (1 .O or 10.0 increased in both controls and DA-depleted animals. Systemic administration of the Dl-like antagonist SCH 23390 (0.05 or 0.2 or DZlike agonist quinpirole (0.5 or 1.0 decreased in both groups of animals. DA-depleted animals exhibited a larger response than did controls to the lower doses of these drugs. Intra administration of clebopride (10 PM) increased in DA-depleted animals. Finally, basal and clebopride-stimulated were unaffected by the repeated microdialysis sessions. These data demonstrate that the reciprocal modulation of , seen in controls and in rats depleted of DA as adults, is also present in adults depleted of DA as
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