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(1988)
Fratantoni JC . lnactivation of virus in blood products ( editorial )
Sieber Sieber (1987)
Merocyanine 540Photochem Photobiol, 46
F. Sieber, J. O'Brien, G. Krueger, Sheri Schober, W. Burns, S. Sharkis, L. Sensenbrenner (1987)
ANTIVIRAL ACTIVITY OF MEROCYANINE 540Photochemistry and Photobiology, 46
J. Feix, B. Kalyanaraman, C. Chignell, R. Hall (1988)
Direct observation of singlet oxygen production by merocyanine 540 associated with phosphatidylcholine liposomes.The Journal of biological chemistry, 263 33
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Procedures for the inactivation of viruses in clotting factor concentratesAmerican Journal of Hematology, 23
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Merocyanine 540 as a fluorescent probe of membranes: Selective staining of leukemic and immature hemopoietic cellsCell, 13
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Binding of merocyanine 540 to normal and leukemic erythroid cellsCell, 20
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Merocyanine 540 as a fluorescent probe of membranes: staining of electrically excitable cellsCell, 13
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ELIMINATION OF RESIDUAL TUMOR CELLS FROM AUTOLOGOUS BONE MARROW GRAFTS BY DYE‐MEDIATED PHOTOLYSIS: PRECLINICAL DATA *Photochemistry and Photobiology, 46
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Lytle Lytle, Budacz Budacz, Keville Keville, Miller Miller, Prodouz Prodouz
Differential inactivation of surrogate viruses with merocyanine 540Photochem Photobiol
D. Valenzeno, J. Trudgen, Angela Hutzenbuhler, M. Milne (1987)
SINGLET OXYGEN INVOLVEMENT IN PHOTOHEMOLYSIS SENSITIZED BY MEROCYANINE‐540 and ROSE BENGALPhotochemistry and Photobiology, 46
Neyndorff Hc, Bartel Dl, F. Tufaro, Levy Jg (1990)
Development of a model to demonstrate photosensitizer‐mediated viral inactivation in bloodTransfusion, 30
Laboratory of Cellular Hematology
C. Korzeniewski, D. Callewaert (1983)
An enzyme-release assay for natural cytotoxicity.Journal of immunological methods, 64 3
Absorption and emission characteristics of merocyanine 540 in microemulsions ( letter )
Jamieson Jamieson, McDonald McDonald, Levy Levy (1990)
Preferential uptake of benzoporphyrin derivative by leukemic versus normal cellsLeuk Res, 14
(1989)
Use of photochemical procedures to inactivate Viruses in platelet suspensions ( abstract )
J. Matthews, J. Newman, F. Sogandares-Bernal, M. Judy, H. Skiles, J. Leveson, A. Marengo-Rowe, T. Chanh (1988)
Photodynamic therapy of viral contaminants with potential for blood banking applicationsTransfusion, 28
Division of Cytokine Biology
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Characterization of the platelet response to exogenous arachidonic acid.Thrombosis research, 22 1-2
B. Kalyanaraman, J. Feix, F. Sieber, J. Thomas, A. Girotti (1987)
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Use of laser - W for inactivation of virus in
(1989)
Inadvation of Friend erythroleukemia virus and Friend virus - transformed cells by merccyanine 540 - mediated pho - tosensitization
(1988)
lnactivation of virus in blood products (editorial)
Gulliya Gulliya, Matthews Matthews, Fay Fay, Dowben Dowben (1988)
Increased survival of normal cells during laser photodynamic therapy: implications for ex vivo autologous bone marrow purgingLife Sci, 42
(1987)
produds
(1987)
Use of laserW for inactivation of virus in blood produds
Joseph Fratantoni, B. Poindexter (1990)
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Food and Drug Administration, Bldg. 29/ Room 329, 8800 Rochille Pike, Bcthesda, MD 20892
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Numerical relations between lysogenic bacteria and particles of bacteriophage
(1987)
Mcmcyanine 540
The effect of the photosensitizer merocyanine 540 (MC 540) on platelets and on three marker viruses was examined to assess its potential in reducing virus transmission by blood products. The results demonstrated several deleterious effects of MC 540 (4–24 micrograms/mL) on platelet morphology and function in both the absence and presence of light (450‐ 600 nm). Treatment of washed platelets with MC 540 in the dark resulted in a significant release of serotonin in the absence of added agonist, as well as a diminished response to thrombin as measured in vitro. In addition, photosensitization caused spontaneous platelet aggregation and release of 92 percent of the releasable serotonin without the addition of an agonist. Because photo‐treatment of blood products is likely to be performed in a protein‐rich medium, the influence of albumin on the phototoxic effects on platelets was assessed. Albumin added to the suspension medium at concentrations greater than or equal to 1.0 percent protected the platelets against the effects of MC 540 in the dark, whereas 5‐percent albumin was required for protection against the phototoxic effects of MC 540 on the platelet response to thrombin. The antiviral activity of MC 540 and light was examined by using the lipid‐containing viruses herpes simplex virus (HSV) and bacteriophages phi 6 and PM2. Of the lipid‐enveloped viruses, HSV was 25 times more photosensitive to MC 540 than was phi 6 (15 micrograms/mL). PM2, which has an internal lipid layer, was almost 300 times less sensitive to MC 540 and light than was HSV. Photoinactivation of φ6 and PM2 (by 18 J/cm2) was completely prevented by the addition of 5‐percent albumin to the medium. Under these conditions, HSV was still inactivated but was nearly 200 times less sensitive. Therefore, the addition of albumin to protect platelets from damage induced by treatment with MC 540 and light reduced markedly the inactivation or viruses by such treatment.
Transfusion – Wiley
Published: Jun 1, 1991
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