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- Publisher
- Springer Journals
- Copyright
- Copyright © 2014 by Springer-Verlag Berlin Heidelberg
- Subject
- Life Sciences; Microbiology; Microbial Genetics and Genomics; Biotechnology
- ISSN
- 0175-7598
- eISSN
- 1432-0614
- DOI
- 10.1007/s00253-013-5494-5
- pmid
- 24425304
- Publisher site
- See Article on Publisher Site
Abstract
The biosynthesis of polyhydroxyalkanoate copolymers in Escherichia coli from unrelated carbon sources becomes attractive nowadays. We previously developed a poly(hydroxybutyrate-co-hydroxyvalerte) (PHBV) biosynthetic pathway from an unrelated carbon source via threonine metabolic route in E. coli (Chen et al., Appl Environ Microbiol 77:4886-4893, 2011). In our study, a citramalate pathway was introduced in recombinant E. coli by cloning a cimA gene from Leptospira interrogans. By blocking the pyruvate and the propionyl-CoA catabolism and replacing the β-ketothiolase gene, the PHBV with 11.5 mol% 3HV fraction was synthesized. Further, the combination of citramalate pathway with the threonine biosynthesis pathway improved the 3HV fraction in PHBV copolymer to 25.4 mol% in recombinant E. coli.
Journal
Applied Microbiology and Biotechnology – Springer Journals
Published: Jan 15, 2014