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The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1

The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1 TASK‐1 encodes an acid‐ and anaesthetic‐sensitive background K+ current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate that TASK‐1, unlike the other two pore (2P) domain K+ channels, is directly blocked by submicromolar concentrations of the endocannabinoid anandamide, independently of the CB1 and CB2 receptors. In cerebellar granule neurons, anandamide also blocks the TASK‐1 standing‐outward K+ current, IKso, and induces depolarization. Anandamide‐induced neurobehavioural effects are only partly reversed by antagonists of the cannabinoid receptors, suggesting the involvement of alternative pathways. TASK‐1 constitutes a novel sensitive molecular target for this endocannabinoid. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The EMBO Journal Wiley

The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1

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References (68)

Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc
ISSN
0261-4189
eISSN
1460-2075
DOI
10.1093/emboj/20.1.47
pmid
11226154
Publisher site
See Article on Publisher Site

Abstract

TASK‐1 encodes an acid‐ and anaesthetic‐sensitive background K+ current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate that TASK‐1, unlike the other two pore (2P) domain K+ channels, is directly blocked by submicromolar concentrations of the endocannabinoid anandamide, independently of the CB1 and CB2 receptors. In cerebellar granule neurons, anandamide also blocks the TASK‐1 standing‐outward K+ current, IKso, and induces depolarization. Anandamide‐induced neurobehavioural effects are only partly reversed by antagonists of the cannabinoid receptors, suggesting the involvement of alternative pathways. TASK‐1 constitutes a novel sensitive molecular target for this endocannabinoid.

Journal

The EMBO JournalWiley

Published: Mar 15, 2002

Keywords: ; ; ;

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