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S. Hoyer (1993)
Intermediary metabolism disturbance in AD/SDAT and its relation to molecular eventsProgress in Neuro-Psychopharmacology and Biological Psychiatry, 17
K. Honda, Mark Smith, Xiongwei Zhu, Diane Baus, W. Merrick, A. Tartakoff, T. Hattier, Peggy Harris, S. Siedlak, H. Fujioka, Quan Liu, P. Moreira, F. Miller, A. Nunomura, S. Shimohama, George Perry (2005)
Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron*Journal of Biological Chemistry, 280
R. Castellani, Peggy Harris, L. Sayre, J. Fujii, N. Taniguchi, M. Vitek, H. Founds, C. Atwood, George Perry, Mark Smith (2001)
Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(Carboxymethyl) lysine and hexitol-lysineFree Radical Biology and Medicine, 31
P. Coskun, M. Beal, D. Wallace (2004)
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.Proceedings of the National Academy of Sciences of the United States of America, 101 29
C. Rottkamp, C. Atwood, J. Joseph, A. Nunomura, George Perry, Mark Smith (2002)
The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer diseasePeptides, 23
M. Mańczak, T. Anekonda, E. Henson, Byung Park, J. Quinn, P. Reddy (2006)
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression.Human molecular genetics, 15 9
A. Klegeris, P. Mcgeer (1997)
beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate.Journal of neuroscience research, 49 2
A. Nunomura, George Perry, M. Pappolla, R. Friedland, K. Hirai, S. Chiba, Mark Smith (2000)
Neuronal Oxidative Stress Precedes Amyloid‐β Deposition in Down SyndromeJNEN: Journal of Neuropathology & Experimental Neurology, 59
U. Brunk, C. Jones, R. Sohal (1992)
A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis.Mutation research, 275 3-6
M. Smith, A. Nunomura, X. Zhu, A. Takeda, George Perry (2000)
Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease.Antioxidants & redox signaling, 2 3
J. Keller, Keith Hanni, W. Markesbery (2000)
Impaired Proteasome Function in Alzheimer's DiseaseJournal of Neurochemistry, 75
S. Minoshima, B. Giordani, S. Berent, K. Frey, N. Foster, D. Kuhl (1997)
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's diseaseAnnals of Neurology, 42
S. Seshadri, A. Beiser, J. Selhub, P. Jacques, I. Rosenberg, R. D'Agostino, P. Wilson, P. Wolf (2002)
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's DiseaseThe New England Journal of Medicine, 346
S. Varadarajan, S. Yatin, M. Aksenova, D. Butterfield (2000)
Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity.Journal of structural biology, 130 2-3
S. Mruthinti, A. Sood, C. Humphrey, S. Swamy-Mruthinti, J. Buccafusco (2006)
The induction of surface β-amyloid binding proteins and enhanced cytotoxicity in cultured PC-12 and IMR-32 cells by advanced glycation end productsNeuroscience, 142
K. Chandrasekaran, T. Giordano, D. Brady, J. Stoll, L. Martin, S. Rapoport (1994)
Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease.Brain research. Molecular brain research, 24 1-4
R. Mark, M. Lovell, W. Markesbery, K. Uchida, M. Mattson (1997)
A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐PeptideJournal of Neurochemistry, 68
M. Vitek, K. Bhattacharya, J. Glendening, E. Stopa, H. Vlassara, R. Bucala, K. Manogue, A. Cerami (1994)
Advanced glycation end products contribute to amyloidosis in Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America, 91 11
Xiongwei Zhu, Mark Smith, George Perry, G. Aliev (2004)
Mitochondrial failures in Alzheimer's diseaseAmerican Journal of Alzheimer's Disease and Other Dementias, 19
Neil Ward, Huu Hao, Sakurai Kenji (1998)
Copper, iron and zinc in Alzheimer's disease senile plaquesJournal of the Neurological Sciences, 158
Thomas Reinheckel, Oliver Ullrich, N. Sitte, Tilman Grune (2000)
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress.Archives of biochemistry and biophysics, 377 1
D. Loeffler, Peter LeWitt, P. Juneau, Anders Sima, Huong Nguyen, A. DeMaggio, C. Brickman, Gregory Brewer, R. Dick, M. Troyer, L. Kanaley (1996)
Increased regional brain concentrations of ceruloplasmin in neurodegenerative disordersBrain Research, 738
D. Schubert, M. Chevion (1995)
The role of iron in beta amyloid toxicity.Biochemical and biophysical research communications, 216 2
Charles Smith, J. Carney, P. Starke-Reed, C. Oliver, E. Stadtman, R. Floyd, W. Markesbery (1991)
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America, 88 23
Akira Tamaoka, Fumiko Miyatake, S. Matsuno, K. Ishii, S. Nagase, Naruhiko Sahara, Seiitsu Ono, Hiroshi Mori, Koichi Wakabayashi, Shoji Tsuji, Haruhiko Takahashi, Shin'ichi Shoji (2000)
Apolipoprotein E allele–dependent antioxidant activity in brains with Alzheimer’s diseaseNeurology, 54
A. Nunomura, George Perry, M. Pappolla, R. Wade, K. Hirai, S. Chiba, Mark Smith (1999)
RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s DiseaseThe Journal of Neuroscience, 19
A. Mezzetti, S. Pierdomenico, F. Costantini, F. Romano, D. Cesare, F. Cuccurullo, T. Imbastaro, G. Riario-Sforza, F. Giacomo, G. Zuliani, R. Fellin (1998)
Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases.Free radical biology & medicine, 25 6
J. Torre (1997)
Cerebromicrovascular Pathology in Alzheimer’s Disease Compared to Normal AgingGerontology, 43
M. Ramsden, L. Plant, N. Webster, P. Vaughan, Z. Henderson, H. Pearson (2001)
Differential effects of unaggregated and aggregated amyloid β protein (1–40) on K+ channel currents in primary cultures of rat cerebellar granule and cortical neuronesJournal of Neurochemistry, 79
Flavio Kamenetz, T. Tomita, Helen Hsieh, G. Seabrook, D. Borchelt, T. Iwatsubo, S. Sisodia, R. Malinow (2003)
APP Processing and Synaptic FunctionNeuron, 37
H. Lüth, M. Holzer, U. Gärtner, M. Staufenbiel, T. Arendt (2001)
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer’s disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathologyBrain Research, 913
R. Nixon, J. Wegiel, Asok Kumar, W. Yu, C. Peterhoff, A. Cataldo, A. Cuervo (2005)
Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy StudyJNEN: Journal of Neuropathology & Experimental Neurology, 64
C. Harrington, C. Colaco (1994)
A glycation connectionNature, 370
E. Streck, C. Matté, Paula Vieira, T. Calcagnotto, C. Wannmacher, M. Wajner, A. Wyse (2003)
Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia.Biochimica et biophysica acta, 1637 3
M. Glickman, A. Ciechanover (2002)
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.Physiological reviews, 82 2
George Perry, R. Friedman, G. Shaw, V. Chau (1987)
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.Proceedings of the National Academy of Sciences of the United States of America, 84 9
A. Cataldo, C. Thayer, E. Bird, T. Wheelock, R. Nixon (1990)
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal originBrain Research, 513
K. McNaught, C. Mytilineou, Ruth Jnobaptiste, J. Yabut, P. Shashidharan, P. Jenner, C. Olanow (2002)
Impairment of the ubiquitin‐proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic culturesJournal of Neurochemistry, 81
Z. Nagy, M. Esiri, M. Legris, P. Matthews (1999)
Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathologyActa Neuropathologica, 97
D. Butterfield, J. Drake, C. Pocernich, Alessandra Castegna (2001)
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide.Trends in molecular medicine, 7 12
H. Lüth, G. Münch, T. Arendt (2002)
Aberrant expression of NOS isoforms in Alzheimer’s disease is structurally related to nitrotyrosine formationBrain Research, 953
Qunxing Ding, Kristi Reinacker, E. Dimayuga, Vidya Nukala, J. Drake, D. Butterfield, Jay Dunn, Sarah Martin, A. Bruce-Keller, J. Keller (2003)
Role of the proteasome in protein oxidation and neural viability following low‐level oxidative stressFEBS Letters, 546
A. Nunomura, George Perry, K. Hirai, G. Aliev, A. Takeda, S. Chiba, M. Smith (1999)
Neuronal RNA Oxidation in Alzheimer's Disease and Down's SyndromeAnnals of the New York Academy of Sciences, 893
G. Münch, J. Thome, P. Foley, R. Schinzel, P. Riederer (1997)
Advanced glycation endproducts in ageing and Alzheimer's diseaseBrain Research Reviews, 23
H. Akiyama, S. Barger, S. Barnum (2000)
INFLAMMATION AND ALZHEIMERS DISEASE, 21
Mark Smith, Peggy Harris, L. Sayre, J. Beckman, George Perry (1997)
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s DiseaseThe Journal of Neuroscience, 17
R. Castellani, P. Harris, L. Sayre, J. Fujii, N. Taniguchi, M. Vitek, H. Founds, C. Atwood, G. Perry, M. Smith (2001)
Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.Free radical biology & medicine, 31 2
S. Yan, A. Roher, Michael Chaney, B. Zlokovic, Ann Schmidt, David Stern (2000)
Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide.Biochimica et biophysica acta, 1502 1
P. Eikelenboom, R. Veerhuis (1996)
The role of complement and activated microglia in the pathogenesis of Alzheimer's diseaseNeurobiology of Aging, 17
G. Münch, R. Schinzel, C. Loske, A. Wong, N. Durany, J. Li, H. Vlassara, M. Smith, George Perry, P. Riederer (1998)
Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproductsJournal of Neural Transmission, 105
M. Ramsden, Z. Henderson, H. Pearson (2002)
Modulation of Ca2+ channel currents in primary cultures of rat cortical neurones by amyloid β protein (1–40) is dependent on solubility statusBrain Research, 956
W. Reynolds, Jennifer Rhees, D. Maciejewski, T. Paladino, H. Sieburg, R. Maki, E. Masliah (1999)
Myeloperoxidase Polymorphism Is Associated with Gender Specific Risk for Alzheimer's DiseaseExperimental Neurology, 155
Qunxing Ding, E. Dimayuga, Sarah Martin, A. Bruce-Keller, Vidya Nukala, A. Cuervo, J. Keller (2003)
Characterization of chronic low‐level proteasome inhibition on neural homeostasisJournal of Neurochemistry, 86
R. Mark, Z. Pang, J. Geddes, K. Uchida, M. Mattson (1997)
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid PeroxidationThe Journal of Neuroscience, 17
M. Smith, P. Harris, L. Sayre, George Perry (1997)
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.Proceedings of the National Academy of Sciences of the United States of America, 94 18
D. Cottrell, E. Blakely, M. Johnson, Paul Ince, D. Turnbull (2001)
Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in ADNeurology, 57
I. Maurer, S. Zierz, H. Möller (2000)
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patientsNeurobiology of Aging, 21
H. Bernstein, H. Kirschke, B. Wiederanders, D. Schmidt, A. Rinne (1990)
Antigenic expression of cathepsin B in aged human brainBrain Research Bulletin, 24
M. Smith, S. Taneda, P. Richey, S. Miyata, S. Yan, D. Stern, L. Sayre, V. Monnier, George Perry (1994)
Advanced Maillard reaction end products are associated with Alzheimer disease pathologyProceedings of the National Academy of Sciences of the United States of America, 92
H. Akiyama, S. Barger, S. Barnum, B. Bradt, J. Bauer, G. Cole, N. Cooper, P. Eikelenboom, M. Emmerling, B. Fiebich, C. Finch, S. Frautschy, W. Griffin, H. Hampel, M. Hull, G. Landreth, L. Lue, R. Mrak, I. Mackenzie, P. Mcgeer, M. O’Banion, J. Pachter, G. Pasinetti, C. Plata-salamán, J. Rogers, R. Rydel, Yong Shen, W. Streit, R. Strohmeyer, Ikuo Tooyoma, F. Muiswinkel, R. Veerhuis, D. Walker, S. Webster, Beatrice Wegrzyniak, G. Wenk, T. Wyss-Coray (2000)
Inflammation and Alzheimer’s diseaseNeurobiology of Aging, 21
P. Sullivan, Nataša Dragičević, Jian‐Hong Deng, Yidong Bai, E. Dimayuga, Qunxing Ding, Qinghua Chen, A. Bruce-Keller, J. Keller (2004)
Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover*Journal of Biological Chemistry, 279
U. Brunk, J. Neuzil, J. Eaton (1998)
Lysosomal involvement in apoptosis.Redox report : communications in free radical research, 6 2
U. Brunk, A. Terman (2002)
The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis.European journal of biochemistry, 269 8
P. Seubert, C. Vigo‐Pelfrey, F. Esch, Michael Lee, H. Dovey, D. Davis, S. Sinha, Michael Schiossmacher, J. Whaley, C. Swindlehurst, R. McCormack, R. Wolfert, D. Selkoe, I. Lieberburg, D. Schenk (1992)
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluidsNature, 359
E. Hol, F. Leeuwen, D. Fischer (2005)
The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1.Trends in molecular medicine, 11 11
D. Radisky, J. Kaplan (1998)
Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts.The Biochemical journal, 336 ( Pt 1)
L Iversen, R Mortishire-Smith, S. Pollack, M. Shearman (1995)
The toxicity in vitro of beta-amyloid protein.The Biochemical journal, 311 ( Pt 1)
V. Reddy, M. Obrenovich, C. Atwood, George Perry, Mark Smith (2009)
Involvement of maillard reactions in Alzheimer diseaseNeurotoxicity Research, 4
F. Muiswinkel, R. Veerhuis, P. Eikelenboom (1996)
Amyloid β Protein Primes Cultured Rat Microglial Cells for an Enhanced Phorbol 12‐Myristate 13‐Acetate‐Induced Respiratory Burst ActivityJournal of Neurochemistry, 66
A. Kontush, C. Berndt, W. Weber, V. Akopyan, S. Arlt, S. Schippling, U. Beisiegel (2001)
Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma.Free radical biology & medicine, 30 1
M. Anderson, J. Requena, J. Crowley, S. Thorpe, J. Heinecke (1999)
The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation.The Journal of clinical investigation, 104 1
A. Cataldo, D. Hamilton, R. Nixon (1994)
Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer diseaseBrain Research, 640
D. Gray, J. Woulfe (2005)
Lipofuscin and aging: a matter of toxic waste.Science of aging knowledge environment : SAGE KE, 2005 5
L. Devi, B. Prabhu, D. Galati, N. Avadhani, H. Anandatheerthavarada (2006)
Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer’s Disease Brain Is Associated with Mitochondrial DysfunctionThe Journal of Neuroscience, 26
G. Casadesus, Mark Smith, Xiongwei Zhu, G. Aliev, A. Cash, K. Honda, R. Petersen, George Perry (2004)
Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species.Journal of Alzheimer's disease : JAD, 6 2
C. Rottkamp, A. Raina, X. Zhu, E. Gaier, A. Bush, C. Atwood, M. Chevion, George Perry, M. Smith (2001)
Redox-active iron mediates amyloid-beta toxicity.Free radical biology & medicine, 30 4
Hyoung-Gon Lee, G. Casadesus, Xiongwei Zhu, A. Takeda, George Perry, Mark Smith (2004)
Challenging the Amyloid Cascade Hypothesis: Senile Plaques and Amyloid‐β as Protective Adaptations to Alzheimer DiseaseAnnals of the New York Academy of Sciences, 1019
A. Schapira, H. Reichmann (1994)
Electron transport chain defects in Alzheimer's disease.Neurology, 45 3 Pt 1
G. Gibson, K. Sheu, J. Blass (1998)
Abnormalities of mitochondrial enzymes in Alzheimer diseaseJournal of Neural Transmission, 105
W. Parker, W. Parker, N. Mahr, C. Filley, J. Parks, D. Hughes, D. Young, C. Cullum (1994)
Reduced platelet cytochrome c oxidase activity in Alzheimer's diseaseNeurology, 44
Mark Smith, G. Casadesus, J. Joseph, George Perry (2002)
Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brainFree Radical Biology and Medicine, 33
E. Podrez, D. Schmitt, H. Hoff, S. Hazen (1999)
Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro.The Journal of clinical investigation, 103 11
Jenny Li, M. Surini, S. Catsicas, E. Kawashima, C. Bouras (1995)
Age-dependent accumulation of advanced glycosylation end products in human neuronsNeurobiology of Aging, 16
J. Thome, G. Münch, R. Müller, R. Schinzel, J. Kornhuber, D. Blum-Degen, L. Sitzmann, M. Rösler, A. Heidland, P. Riederer (1996)
Advanced glycation endproducts-associated parameters in the peripheral blood of patients with Alzheimer's disease.Life sciences, 59 8
J. Connor, E. Milward, E. Milward, E. Milward, S. Moalem, M. Sampietro, P. Boyer, M. Percy, M. Percy, M. Percy, C. Vergani, R. Scott, M. Chorney (2001)
Is hemochromatosis a risk factor for Alzheimer's disease?Journal of Alzheimer's disease : JAD, 3 5
Alessandra Castegna, V. Thongboonkerd, J. Klein, B. Lynn, W. Markesbery, D. Butterfield (2003)
Proteomic identification of nitrated proteins in Alzheimer's disease brainJournal of Neurochemistry, 85
J. Keller, J. Gee, Qunxing Ding (2002)
The proteasome in brain agingAgeing Research Reviews, 1
K. Williamson, S. Gabbita, Shenyun Mou, M. West, Q. Pye, W. Markesbery, R. Cooney, P. Grammas, U. Reimann‐Philipp, R. Floyd, K. Hensley (2002)
The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer BrainNitric Oxide, 6
D. Butterfield, A. Bush (2004)
Alzheimer’s amyloid β-peptide (1–42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptideNeurobiology of Aging, 25
J. Khoury, S. Hickman, C. Thomas, L. Cao, S. Silverstein, J. Loike (1996)
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils.Nature, 382 6593
K. Hiller, K. Asmus (1981)
Tl2+ and Ag2+ metal-ion-induced oxidation of methionine in aqueous solution. A pulse radiolysis study.International journal of radiation biology and related studies in physics, chemistry, and medicine, 40 6
Z. Guan, Ya-Nan Wang, Nigel Cairns, P. Lantos, G. Dallner, P. Sindelar (1999)
Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.Journal of neuropathology and experimental neurology, 58 7
Ming Zhao, F. Antunes, J. Eaton, U. Brunk (2003)
Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis.European journal of biochemistry, 270 18
S. Bondy, S. Guo-Ross, A. Truong (1998)
Promotion of transition metal-induced reactive oxygen species formation by β-amyloidBrain Research, 799
M. Soriani, D. Pietraforte, M. Minetti (1994)
Antioxidant potential of anaerobic human plasma: role of serum albumin and thiols as scavengers of carbon radicals.Archives of biochemistry and biophysics, 312 1
A. Cataldo, P. Paskevich, Eiki Kominami, Ralph Nixon (1991)
Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America, 88 24
A. Palmer, M. Burns (1994)
Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's diseaseBrain Research, 645
K. Williamson, S. Gabbita, Shenyun Mou, M. West, Q. Pye, W. Markesbery, R. Cooney, P. Grammas, U. Reimann‐Philipp, R. Floyd, K. Hensley (2002)
The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain.Nitric oxide : biology and chemistry, 6 2
A. Kontush (2001)
Amyloid-beta: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease.Free radical biology & medicine, 31 9
C. Rottkamp, A. Raina, Xiongwei Zhu, E. Gaier, A. Bush, C. Atwood, M. Chevion, George Perry, Mark Smith (2001)
Redox-active iron mediates amyloid-β toxicityFree Radical Biology and Medicine, 30
R. Castellani, M. Smith, A. Nunomura, P. Harris, George Perry (1999)
Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?Free radical biology & medicine, 26 11-12
L. Sayre, D. Zelasko, Peggy Harris, George Perry, R. Salomon, Mark Smith (1997)
4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's DiseaseJournal of Neurochemistry, 68
S. Lynch, B. Frei (1997)
Physiological thiol compounds exert pro- and anti-oxidant effects, respectively, on iron- and copper-dependent oxidation of human low-density lipoprotein.Biochimica et biophysica acta, 1345 2
C. Behl, J. Davis, R. Lesley, D. Schubert (1994)
Hydrogen peroxide mediates amyloid beta protein toxicity.Cell, 77 6
Yu Nakamura, M. Takeda, Hideo Suzuki, H. Hattori, K. Tada, S. Hariguchi, S. Hashimoto, T. Nishimura (1991)
Abnormal distribution of cathepsins in the brain of patients with Alzheimer's diseaseNeuroscience Letters, 130
Mark Smith, P. Richey, S. Taneda, R. Kutty, L. Sayre, V. Monnier, George Perry (1994)
Advanced Maillard Reaction End Products, Free Radicals, and Protein Oxidation in Alzheimer's Disease aAnnals of the New York Academy of Sciences, 738
Mark Smith, M. Rudnicka-Nawrot, P. Richey, D. Praprotnik, P. Mulvihill, C. Miller, L. Sayre, George Perry (1995)
Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's DiseaseJournal of Neurochemistry, 64
M. Smith, George Perry, P. Richey, L. Sayrec, V. Anderson, M. Beal, N. Kowall (1996)
Oxidative damage in Alzheimer'sNature, 382
M. Unnikrishnan, M. Rao (1990)
Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfoneAgents and Actions, 31
V. Shuvaev, Isabelle Laffont, J. Sérot, J. Fujii, N. Taniguchi, G. Siest (2001)
Increased protein glycation in cerebrospinal fluid of Alzheimer’s disease 2 2 Abbreviations: AD, Alzheimer’s disease; AGEs, advanced glycation end products; apo, apolipoprotein; BSA, bovine serum albumin; CSF, cerebrospinal fluid; ELISA, enzyme-linked immunosorbent assay; PBS, phosphate buffeNeurobiology of Aging, 22
R. Castellani, K. Hirai, G. Aliev, K. Drew, A. Nunomura, A. Takeda, A. Cash, M. Obrenovich, George Perry, Mark Smith (2002)
Role of mitochondrial dysfunction in Alzheimer's diseaseJournal of Neuroscience Research, 70
A. Kontush, C. Berndt, W. Weber, V. Akopyan, S. Arlt, S. Schippling, U. Beisiegel (2001)
Amyloid-β is an antioxidant for lipoproteins in cerebrospinal fluid and plasmaFree Radical Biology and Medicine, 30
L. Ko, Eric Ko, P. Nacharaju, Wan‐Kyng Liu, E. Chang, Á. Kenessey, S. Yen (1999)
An immunochemical study on tau glycation in paired helical filamentsBrain Research, 830
(2001)
Amyloid - beta peptides are cytotoxic to oligodendrocytes
R. Mrak, J. Sheng, W. Griffin (1996)
Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimer's DiseaseJournal of Neuropathology and Experimental Neurology, 55
J. Keller, W. Markesbery (2000)
Proteasome inhibition results in increased poly‐ADP‐ribosylation: Implications for neuron deathJournal of Neuroscience Research, 61
A. Kontush (2001)
Amyloid-β: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer’s diseaseFree Radical Biology and Medicine, 31
Mary Walter, P. Mason, R.Preston Mason (1997)
Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.Biochemical and biophysical research communications, 233 3
M. Lovell, W. Ehmann, Steven Butler, W. Markesbery (1995)
Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's diseaseNeurology, 45
W. Markesbery, M. Lovell (1998)
Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s DiseaseNeurobiology of Aging, 19
J. Blass, G. Gibson (1999)
Cerebrometabolic Aspects of Delirium in Relationship to DementiaDementia and Geriatric Cognitive Disorders, 10
Xudong Huang, C. Atwood, M. Hartshorn, G. Multhaup, L. Goldstein, R. Scarpa, M. Cuajungco, Danielle Gray, James Lim, R. Moir, R. Tanzi, A. Bush (1999)
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.Biochemistry, 38 24
C. Harrington, C. Colaço (1994)
Alzheimer's disease. A glycation connection.Nature, 370 6487
P. Good, Peter, Werner, A. Hsu, C. Warren, Olanow, Daniel Perl (1996)
Evidence of neuronal oxidative damage in Alzheimer's disease.The American journal of pathology, 149 1
Mark Smith, L. Sayre, V. Monnier, George Perry (1995)
Radical AGEing in Alzheimer's diseaseTrends in Neurosciences, 18
Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.
Cellular and Molecular Life Sciences – Springer Journals
Published: Jul 2, 2007
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