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- Publisher
- Annual Reviews
- Copyright
- Copyright 1993 Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0066-4197
- eISSN
- 1545-2948
- DOI
- 10.1146/annurev.ge.27.120193.002433
- pmid
- 8122910
- Publisher site
- See Article on Publisher Site
Abstract
Intercellular signaling and signal transduction underlie most aspects of development and behavior. To understand any specific case we must identify the ligands, receptors and transducers, as well as regulators that modulate the activity of the signaling pathway. To understand more general aspects of signaling, we have to address the questions: To what extent are there 0066-4197/93/1215-0497$02.00 STERNBERG modular signaling pathways, i.e. pathways that act as coherent units? How many such pathways are there? What factors affect the action of a universal pathway in particular cases? How widely is a given component or pathway used? How are the effects of multiple signaling pathways integrated? Here I discuss the use of Caenorhabditis elegans molecular genetics to study problems of intercellular signaling and signal transduction. Several main features of genetics C. elegans have driven the study of problems in cell and molecular biology over the past few years. First is the powerful (11). The small size and rapid generation time allow large-scale mutant hunts and, in particular, extragenic suppressor and enhancer analysis. The simple anatomy and development, observable at single-cell resolution under Nomarski optics, allows rapid examination of phenotypes (reviewed in (reviewed in 122). In addition, one can correlate individual neurons
Journal
Annual Review of Genetics – Annual Reviews
Published: Dec 1, 1993