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Potassium‐stimulated release of nitric oxide from cerebellar slices

Potassium‐stimulated release of nitric oxide from cerebellar slices This study shows that nitric oxide release can be evoked from intact neuronal tissue. Stimulation of rat cerebellar slices for 4 min with 50 mM potassium significantly increased the release of nitric oxide and glutamate and was associated with a rise in the guanosine 3′:5′‐cyclic monophosphate (cyclic GMP) content of the tissue. Nitric oxide levels in the perfusate increased from 160 to 262 parts per billion. It is suggested that an increased release of endogenous glutamate in the slice, induced by exposure to potassium, may mediate the release of nitric oxide. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Potassium‐stimulated release of nitric oxide from cerebellar slices

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References (13)

Publisher
Wiley
Copyright
1990 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1990.tb12078.x
Publisher site
See Article on Publisher Site

Abstract

This study shows that nitric oxide release can be evoked from intact neuronal tissue. Stimulation of rat cerebellar slices for 4 min with 50 mM potassium significantly increased the release of nitric oxide and glutamate and was associated with a rise in the guanosine 3′:5′‐cyclic monophosphate (cyclic GMP) content of the tissue. Nitric oxide levels in the perfusate increased from 160 to 262 parts per billion. It is suggested that an increased release of endogenous glutamate in the slice, induced by exposure to potassium, may mediate the release of nitric oxide.

Journal

British Journal of Pharmacology – Wiley

Published: Sep 1, 1990

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