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The Promise of Biomarkers in Diagnosing Major Depression in Primary Care: the Present and Future

The Promise of Biomarkers in Diagnosing Major Depression in Primary Care: the Present and Future Major depressive disorder (MDD) is the most prevalent psychiatric disorder, but it can be underdiagnosed or misdiagnosed. Most people with depression are seen in primary care settings, where there are limited resources to diagnose and treat the patient. There is a lack of clinically validated objective laboratory-based diagnostic tests to diagnose MDD; however, it is clear that these tests could greatly improve the correct and timely diagnosis. This review aims to give a cross-sectional view of current efforts of DNA methylomic, transcriptomic, and proteomic approaches to identify biomarkers. We outline our view of the biomarker developmental steps from discovery to clinical application. We then propose that better cooperation will lead us closer to the common goal of identifying biological biomarkers for major depression. “The important thing is not to stop questioning. Curiosity has its own reason for existing.” Albert Einstein. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Psychiatry Reports Springer Journals

The Promise of Biomarkers in Diagnosing Major Depression in Primary Care: the Present and Future

Redei, Eva; Mehta, Neha
Current Psychiatry Reports , Volume 17 (8) – Jun 17, 2015
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References (73)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Psychiatry
ISSN
1523-3812
eISSN
1535-1645
DOI
10.1007/s11920-015-0601-1
pmid
26081681
Publisher site
See Article on Publisher Site

Abstract

Major depressive disorder (MDD) is the most prevalent psychiatric disorder, but it can be underdiagnosed or misdiagnosed. Most people with depression are seen in primary care settings, where there are limited resources to diagnose and treat the patient. There is a lack of clinically validated objective laboratory-based diagnostic tests to diagnose MDD; however, it is clear that these tests could greatly improve the correct and timely diagnosis. This review aims to give a cross-sectional view of current efforts of DNA methylomic, transcriptomic, and proteomic approaches to identify biomarkers. We outline our view of the biomarker developmental steps from discovery to clinical application. We then propose that better cooperation will lead us closer to the common goal of identifying biological biomarkers for major depression. “The important thing is not to stop questioning. Curiosity has its own reason for existing.” Albert Einstein.

Journal

Current Psychiatry Reports – Springer Journals

Published: Jun 17, 2015

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