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Metabolic changes in rabbit spinal cord after trauma: Magnetic resonance spectroscopy studies

Metabolic changes in rabbit spinal cord after trauma: Magnetic resonance spectroscopy studies Combined phosphorus and proton magnetic resonance spectroscopy (MRS), using double‐tuned surface coils, was used to monitor certain metabolic changes in the L‐3 spinal segment of anesthetized rabbits prior to and following experimental spinal cord trauma. Following severe trauma, resulting in spastic paraplegia, there was a delayed and progressive accumulation of lactic acid, a decline in intracellular pH, and a loss of high‐energy phosphates. Maximal alterations occurred between 2 and 3 hours after the trauma, with little further change by 4 hours. Histological examination 2 weeks after trauma showed tissue necrosis and cavitation. These findings support the concept of secondary tissue injury after spinal cord trauma and suggest that early changes in metabolism, as shown by MRS, may predict irreversible tissue damage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Metabolic changes in rabbit spinal cord after trauma: Magnetic resonance spectroscopy studies

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References (32)

Publisher
Wiley
Copyright
Copyright © 1989 The American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410250105
pmid
2913925
Publisher site
See Article on Publisher Site

Abstract

Combined phosphorus and proton magnetic resonance spectroscopy (MRS), using double‐tuned surface coils, was used to monitor certain metabolic changes in the L‐3 spinal segment of anesthetized rabbits prior to and following experimental spinal cord trauma. Following severe trauma, resulting in spastic paraplegia, there was a delayed and progressive accumulation of lactic acid, a decline in intracellular pH, and a loss of high‐energy phosphates. Maximal alterations occurred between 2 and 3 hours after the trauma, with little further change by 4 hours. Histological examination 2 weeks after trauma showed tissue necrosis and cavitation. These findings support the concept of secondary tissue injury after spinal cord trauma and suggest that early changes in metabolism, as shown by MRS, may predict irreversible tissue damage.

Journal

Annals of NeurologyWiley

Published: Jan 1, 1989

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