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T. Mclntosh, Alan Faden, M. Bendall, Robert Vink (1987)
Traumatic Brain Injury in the Rat: Alterations in Brain Lactate and pH as Characterized by 1H and 31P Nuclear Magnetic ResonanceJournal of Neurochemistry, 49
B. Chance, S. Eleff, J. Leigh (1980)
Noninvasive, nondestructive approaches to cell bioenergetics.Proceedings of the National Academy of Sciences of the United States of America, 77 12
J. Prichard, J. Alger, K. Behar, O. Petroff, R. Shulman (1983)
Cerebral metabolic studies in vivo by 31P NMR.Proceedings of the National Academy of Sciences of the United States of America, 80 9
Faden Faden, Sacksen Sacksen, Noble Noble (1988)
Structure activity relationships of TRH analogs in traumatic spinal injuryBrain Res, 448
(1984)
Lipid peroxidation in spinal cord : FeC & induction and protection with antioxidants
K. Allen, A. Busza, H. Crockard, Richard Frackowiak, D. Gadian, E. Proctor, R. Russell, S. Williams (1987)
Acute Cerebral Ischaemia: Concurrent Changes in Cerebral Blood Flow, Energy Metabolites, pH, and Lactate Measured with Hydrogen Clearance and 31P and 1H Nuclear Magnetic Resonance Spectroscopy. III. Changes following IschaemiaJournal of Cerebral Blood Flow & Metabolism, 8
R. Vink, S. Knoblach, A. Faden (1987)
31P magnetic resonance spectroscopy of traumatic spinal cord injuryMagnetic Resonance in Medicine, 5
A. Faden, Christopher Molioneaux, J. Rosenberger, T. Jacobs, B. Cox (1985)
Endogenous opioid immunoreactivity in rat spinal cord following traumatic injuryAnnals of Neurology, 17
Faden Faden (1987)
Opiate‐receptor antagonists, thyrotropin‐releasing hormone (TRH) ana TRH analogs in the treatment of spinal cord injuryCNS Trauma, 4
Hilberman Hilberman, Subramanian Subramanian, Haselgrove Haselgrove (1984)
In vivo time resolved brain phosphorus nuclear magnetic resonance spectroscopyJ Cereb Blood Flow Metab, 4
J. Pettegrew, S. Kopp, J. Dadok, N. Minshew, J. Feliksik, T. Glonek, M. Cohen (1986)
Chemical characterization of a prominent phosphomonoester resonance from mammalian brain. 31P and 1H NMR analysis at 4.7 and 14.1 teslaJournal of Magnetic Resonance, 67
Vink Vink, McIntosh McIntosh, Faden Faden (1988)
The use of non‐edited 1 H NMR lactate/ n ‐acetyl aspartate ratios for in vivo determination of lactate concentration in brainMagn Reson Med, 7
Blood flow , metabolic and neurophysiological mechanisms in spinal cord injury
P. Demediuk, R. Saunders, Douglas Anderson, E. Means, Lloyd Horrocks (1985)
Membrane lipid changes in laminectomized and traumatized cat spinal cord.Proceedings of the National Academy of Sciences of the United States of America, 82 20
N. Ishige, L. Pitts, L. Pogliani, T. Hashimoto, M. Nishimura, H. Bartkowski, T. James (1987)
Effect of hypoxia on traumatic brain injury in rats: Part 2. Changes in high energy phosphate metabolism.Neurosurgery, 20 6
A. Faden, P. Chan, S. Longar (1987)
Alterations in Lipid Metabolism, Na+,K+‐ATPase Activity, and Tissue Water Content of Spinal Cord Following Experimental Traumatic InjuryJournal of Neurochemistry, 48
J. Walker, Ronald Yates, J. O'neill, D. Yashon (1977)
Canine spinal cord energy state after experimental traumaJournal of Neurochemistry, 29
(1987)
hormone (TRH) and TRH analogs in the treatment of spinal cord injury
R. Vink, Tracy McIntosh, A. Faden (1988)
Nonedited 1H NMR lactate/n‐acetyl aspartate ratios and the in vivo determination of lactate concentration in brainMagnetic Resonance in Medicine, 7
Brain injury : neurochemical aspects
A. Faden (1987)
Pharmacotherapy in spinal cord injury: a critical review of recent developments.Clinical neuropharmacology, 10 3
R. Vink, T. Mcintosh, P. Demediuk, M. Weiner, A. Faden (1988)
Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma.The Journal of biological chemistry, 263 2
H. Senter, J. Venes (1979)
Loss of autoregulation and posttraumatic ischemia following experimental spinal cord trauma.Journal of neurosurgery, 50 2
A. Sandler, Charles Tator (1976)
Review of the effect of spinal cord trama on the vessels and blood flow in the spinal cord.Journal of neurosurgery, 45 6
R. Vink, T. Mcintosh, I. Yamakami, A. Faden (1988)
31P NMR characterization of graded traumatic brain injury in ratsMagnetic Resonance in Medicine, 6
M. Hilberman, Harihara Subramanian, J. Haselgrove, J. Cone, John, Egan, Laszlo Gyulai, B. Chance (1984)
In vivo Time-Resolved Brain Phosphorus Nuclear Magnetic ResonanceJournal of Cerebral Blood Flow & Metabolism, 4
A. Faden, I. Sacksen, L. Noble (1988)
Structure-activity relationships of TRH analogs in rat spinal cord injuryBrain Research, 448
(1987)
Opiate-receptor antagonists, thyrotropin-releasing
O. Petroff, J. Prichard, K. Behar, J. Alger, J. Hollander, R. Shulman (1985)
Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopyNeurology, 35
A. Faden, R. Simon (1988)
A potential role for excitotoxins in the pathophysiology of spinal cord injuryAnnals of Neurology, 23
Hypotheses in spinal cord trauma research
M. Décorps, J. Lebas, J. Leviel, S. Confort, C. Rémy, A. Benabid (1984)
Analysis of brain metabolism changes induced by acute potassium cyanide intoxication by 31P NMR in vivo using chronically implanted surface coilsFEBS Letters, 168
Combined phosphorus and proton magnetic resonance spectroscopy (MRS), using double‐tuned surface coils, was used to monitor certain metabolic changes in the L‐3 spinal segment of anesthetized rabbits prior to and following experimental spinal cord trauma. Following severe trauma, resulting in spastic paraplegia, there was a delayed and progressive accumulation of lactic acid, a decline in intracellular pH, and a loss of high‐energy phosphates. Maximal alterations occurred between 2 and 3 hours after the trauma, with little further change by 4 hours. Histological examination 2 weeks after trauma showed tissue necrosis and cavitation. These findings support the concept of secondary tissue injury after spinal cord trauma and suggest that early changes in metabolism, as shown by MRS, may predict irreversible tissue damage.
Annals of Neurology – Wiley
Published: Jan 1, 1989
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