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The interaction between corticosterone and hippocampal 5‐HT1A receptor mRNA expression was investigated in male rats. Two days after adrenalectomy, 5‐HT1A receptor mRNA was increased in the granule cell layer of the dentate gyrus. Injection of corticosterone led to a significant dose‐dependent and transient suppression of 5‐HT1A receptor mRNA. The effect of a low dose of corticosterone (50 μg/kg) could be blocked by RU 28318, a specific mineralocorticoid receptor antagonist, but not by RU 38486, a glucocorticoid antagonist. The effect of a higher dose of corticosterone (300 μg/kg) could be partially blocked by RU 28318, whereas there was no additional effect of RU 38486. These results point to a stringent regulation of hippocampal 5‐HT1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor.
Journal of Neuroendocrinology – Wiley
Published: Aug 1, 1995
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