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Core particles of hepatitis B virus and ground squirrel hepatitis virus. II. Characterization of the protein kinase reaction associated with GSHV and HBVJ Virol, 43
- Publisher
- Wiley
- Copyright
- Copyright © 1985 American Association for the Study of Liver Diseases
- ISSN
- 0270-9139
- eISSN
- 1527-3350
- DOI
- 10.1002/hep.1840050316
- Publisher site
- See Article on Publisher Site
Abstract
The infectivity and host range of ground squirrel hepatitis virus (GSHV) have been further examined by animal inoculation experiments. Although carrier squirrel sera usually harbor 109 to 1010 virions per ml as determined by physical measurements, titration of one such serum revealed that squirrel infectivity was lost following dilution of the sample over 106‐fold. Infectivity is markedly reduced by NP40 pretreatment of infected serum. GSHV infection cannot be readily transmitted to several related ground squirrel species, but chipmunks can be experimentally infected by GSHV virions or by cloned GSHV DNA, and the resulting infection closely resembles that seen in the normal host.
Journal
Hepatology – Wiley
Published: May 1, 1985